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International Journal of Hematology

, Volume 107, Issue 4, pp 478–485 | Cite as

Long-term outcome in patients treated at home during the pancytopenic phase after allogeneic haematopoietic stem cell transplantation

  • Olle Ringdén
  • Behnam Sadeghi
  • Gianluca Moretti
  • Sigrun Finnbogadottir
  • Brita Eriksson
  • Jonas Mattsson
  • Britt-Marie Svahn
  • Mats Remberger
Original Article
  • 144 Downloads

Abstract

Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) were given the option to be treated at home during the pancytopenic phase. Daily visits by a nurse and phone calls from a physician from the unit were part of the protocol. During almost two decades, 252 patients with haematological malignancies and non-malignant disorders were included. Median age was 47 (range 0–72) years. Myeloablative conditioning was given to 102 patients and reduced intensity to 150. Donors were matched unrelated (n = 160), HLA-identical siblings (n = 71), or HLA-mismatched (n = 21). Cumulative incidence of acute graft-versus-host disease (GVHD) was 35% and that of chronic GVHD was 46%. Non-relapse mortality was 14% 10 years after HSCT. In patients with haematological malignancies (n = 229), the 10-year probability of relapse was 34%. No patients died at home. Overall survival was 59% and relapse-free survival was 50% after 10 years. We conclude that patients treated at home after HSCT have an encouraging long-term outcome.

Keywords

Allogeneic hematopoietic stem cell transplantation Home care Neutropenia Graft-versus-host disease 

Notes

Acknowledgements

We thank Inger Holmström and Gunilla Tillinger for excellent preparation of this manuscript. This study was supported by grants from the Swedish Cancer Society (CAN2013/671), the Swedish Research Council (K2014-64X-05971-34-4), the Children’s Cancer Foundation (PR2013-0045), the Cancer Society in Stockholm (111293), and Karolinska Institutet.

Compliance with ethical standards

Disclosure

The authors have no disclosure.

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  1. 1.Department of LABMED, Translational Cell Therapy Research Group (TCR)Karolinska Institutet, Kliniskt Forskningscentrum (KFC)HuddingeSweden
  2. 2.Department of Oncology-PathologyKarolinska InstitutetHuddingeSweden
  3. 3.Centre for Allogeneic Stem Cell TransplantationKarolinska University Hospital HuddingeStockholmSweden

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