International Journal of Hematology

, Volume 107, Issue 2, pp 157–165 | Cite as

Persistent changes in circulating white blood cell populations after splenectomy

  • Minke A. E. Rab
  • Aafke Meerveld-Eggink
  • Heleen van Velzen-Blad
  • Douwe van Loon
  • Ger T. Rijkers
  • Okke de Weerdt
Original Article

Abstract

The effect of splenectomy on the incidence of infections and thromboembolisms has been investigated thoroughly. Nevertheless, the long-term effects of splenectomy on immunological profile and circulating blood counts have not been described before. To study such long-term effects, we analysed several parameters in splenectomised trauma patients and compared the results of this group (“otherwise healthy patients”) to patients with a specific underlying disease. We measured platelet count, leukocytes and differential, lymphocyte subsets, serum levels of immunoglobulins, and complement pathways in 113 patients. Indications to perform a splenectomy were trauma (n = 42), Hodgkin lymphoma (n = 24), hereditary spherocytosis (n = 21), and immune thrombocytopenia (n = 26). In trauma patients lymphocytes and lymphocytes subsets were particularly elevated compared to normal population values. Splenectomised patients with Hodgkin lymphoma had significant lower numbers of T lymphocytes than trauma patients. Significant increases in platelets, leukocytes, and monocytes were observed in patients with hereditary spherocytosis. Occurrence of MBL genotype was different in ITP patients than in other splenectomised groups and the normal population. In splenectomised patients (> 4 years), platelet counts and lymphocyte subsets are increased which persist over time. As a result, these blood counts in splenectomised patients differ from reference values in the normal population.

Keywords

Splenectomy Leukocytes Lymphocyte differential Immunoglobulins Platelet count 

Notes

Acknowledgements

We thank all the patients and laboratory personnel.

Compliance with ethical standards

Conflict of interest

The study was conducted without any financial or commercial relationships. The authors declare there was no conflict of interest.

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  • Minke A. E. Rab
    • 1
    • 5
  • Aafke Meerveld-Eggink
    • 1
  • Heleen van Velzen-Blad
    • 2
  • Douwe van Loon
    • 3
  • Ger T. Rijkers
    • 2
    • 4
  • Okke de Weerdt
    • 1
  1. 1.Department of Internal MedicineSt. Antonius HospitalNieuwegeinThe Netherlands
  2. 2.Department of Medical Microbiology and ImmunologySt. Antonius HospitalNieuwegeinThe Netherlands
  3. 3.Department of Clinical Chemistry and HaematologySt. Antonius HospitalNieuwegeinThe Netherlands
  4. 4.Department of ScienceUniversity College RooseveltMiddelburgThe Netherlands
  5. 5.Department of Internal Medicine and DermatologyUniversity Medical Centre UtrechtUtrechtThe Netherlands

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