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International Journal of Hematology

, Volume 107, Issue 1, pp 105–111 | Cite as

Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction

  • Hirokazu Kurahashi
  • Akiyoshi Takami
  • Kenta Murotani
  • Shingo Numoto
  • Akihisa Okumura
Original Article
  • 167 Downloads

Abstract

This study examined relationships between valproate (VPA) and platelet count and immature platelet fraction (IPF). We compared the platelet count and IPF among three groups of children: those treated with VPA, those treated with other antiepileptic drugs (AEDs), and a reference group. IPF was measured using flow cytometry, and absolute immature platelet count (A-IPC) was calculated. The platelet count was significantly lower in the VPA group than in other AED and reference groups. In all groups, IPF was negatively correlated with platelet count. IPF was significantly higher in the VPA group than in the reference group, whereas A-IPC was similar among all groups. After stratification of the platelet count, IPF and A-IPC of the three groups did not differ significantly in any strata. No relationship was observed between serum VPA level and platelet count, IPF, or A-IPC. Our study suggests that VPA is associated with a decreased platelet count, although thrombocytopoiesis is not affected, even in children with a reduced platelet count. The suppression of platelet production in the bone marrow is unlikely to be the cause of thrombocytopenia in patients treated with VPA.

Keywords

Immature platelet fraction Valproate Serum level Thrombocytopenia 

Notes

Acknowledgements

This study was partially supported by a grant from the Ministry of Health, Labor, and Welfare.

Compliance wit ethical standards

Conflict of interest

The authors have no conflicts of interest relevant to this article to disclose.

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  1. 1.Department of PediatricsAichi Medical UniversityNagakuteJapan
  2. 2.Department of HematologyAichi Medical UniversityNagakuteJapan
  3. 3.Division of Biostatistics, Clinical Research CenterAichi Medical University HospitalNagakuteJapan

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