International Journal of Hematology

, Volume 106, Issue 4, pp 500–507 | Cite as

Trend and treatment patterns of aplastic anemia in Korea, pure red cell aplasia and myelodysplastic syndrome in Korea: a nation-wide analysis

Original Article


Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea. However, there are no exact data regarding its prevalence and frequency of allogeneic hematopoietic cell transplantation (HCT) in Korea. Here, we present demographic data relating to AA/PRCA/MDS in Korea. Data were prepared by retrieval from a computerized database maintained by the National Health Insurance Service and Korea National Statistical Office. HCT data were collected from all HCT centers in Korea. The crude incidence rate of AA decreased from 2002 to 2010 and from 35 to 28 per million persons. Females were more affected by AA. The peak ages of onset of AA were in the seventh decade or older. The frequency of HCT for AA increased from 2002 to 2012 and from 69 to 131 per year. The crude incidence rates of MDS increased from 2002 to 2010, with 8–20 per million persons, and the frequency of HCT also increased, from 30 in 2002 to 132 in 2011. Even allowing for the possibility of overestimation, the crude incidence of AA is significantly higher in Korea than in western countries.


Aplastic anemia Crude incidence Prevalence Treatment 



This work was supported by the Priority Research Center Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science and Technology (2009-0094050). This research was also supported by the Basic Science Research Program through the NRF, which is funded by the Ministry of Education (NRF-2014R1A1A3051393), and the Basic Science Research Program through the Biomedical Research Center, which is funded by the Ulsan University Hospital (UUHBRC-2016-001). We are in debt to Eun Hee Jung in National Health Insurance Service Ilsan Hospital for the devotion to preparing nation-wide basic data of this paper.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.


  1. 1.
    Issaragrisil S, Leaverton PE, Chansung K, Thamprasit T, Porapakham Y, Vannasaeng S, et al. Regional patterns in the incidence of aplastic anemia in Thailand. The Aplastic Anemia Study Group. Am J Hematol. 1999;61:164–8.CrossRefPubMedGoogle Scholar
  2. 2.
    Abkowitz JL, Powell JS, Nakamura JM, Kadin ME, Adamson JW. Pure red cell aplasia: response to therapy with anti-thymocyte globulin. Am J Hematol. 1986;23:363–71.CrossRefPubMedGoogle Scholar
  3. 3.
    Ministry of Health and Welfare, The Korea central cancer registry. Annual report of cancer statistics in Korea in 2008. Seoul: Ministry of Health and Welfare; 2010.Google Scholar
  4. 4.
    Park HJ, Park EH, Jung KW, Kong HJ, Won YJ, Lee JY, et al. Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008. Korean J Hematol. 2012;47:28–38.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Baslar Z, Aktuglu G, Bolaman Z, Buyukkececi F, Gezer S, Kansu E, et al. Incidence of aplastic anemia in Turkey: a hospital-based prospective multicentre study. Leuk Res. 1997;21:1135–9.CrossRefPubMedGoogle Scholar
  6. 6.
    Baumelou E, Guiguet M, Mary JY. Epidemiology of aplastic anemia in France: a case-control study. I. Medical history and medication use. The French Cooperative Group for Epidemiological Study of Aplastic Anemia. Blood. 1993;81:1471–8.PubMedGoogle Scholar
  7. 7.
    Benitez-Aranda H, Velez-Ruelas MA, Diaz-Cardenas S, Sanchez-Valle E, Xolotl-Castillo M, Duenas-Gonzalez MT, et al. Incidence of aplastic anemia in a defined subpopulation from Mexico City. Hematology. 2002;7:229–32.CrossRefPubMedGoogle Scholar
  8. 8.
    Issaragrisil S, Kaufman DW, Anderson T, Chansung K, Leaverton PE, Shapiro S, et al. The epidemiology of aplastic anemia in Thailand. Blood. 2006;107:1299–307.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Szklo M, Sensenbrenner L, Markowitz J, Weida S, Warm S, Linet M. Incidence of aplastic anemia in metropolitan Baltimore: a population-based study. Blood. 1985;66:115–9.PubMedGoogle Scholar
  10. 10.
    Young NS, Kaufman DW. The epidemiology of acquired aplastic anemia. Haematologica. 2008;93:489–92.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  1. 1.Division of Hematology and Cellular Therapy, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea
  2. 2.Department of Hematology and Oncology, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea
  3. 3.Department of Internal Medicine, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea
  4. 4.Department of Policy Research AffairsNational Health Insurance Service Ilsan HospitalIlsanSouth Korea
  5. 5.Division of Oncology-Hematology, Department of Internal MedicineNational Health Insurance Service Ilsan HospitalIlsanSouth Korea
  6. 6.Division of Hematology, Department of Internal MedicineGachon University Gil Medical CenterIncheonSouth Korea

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