International Journal of Hematology

, Volume 106, Issue 4, pp 508–516 | Cite as

Efficacy and safety of eltrombopag in persistent and newly diagnosed ITP in clinical practice

  • Tomás José González-López
  • Fernando Fernández-Fuertes
  • José Angel Hernández-Rivas
  • Blanca Sánchez-González
  • Violeta Martínez-Robles
  • María Teresa Alvarez-Román
  • Gloria Pérez-Rus
  • Cristina Pascual
  • Silvia Bernat
  • Esther Arrieta-Cerdán
  • Carlos Aguilar
  • Abelardo Bárez
  • María Jesús Peñarrubia
  • Pavel Olivera
  • Angeles Fernández-Rodríguez
  • Erik de Cabo
  • Luis Javier García-Frade
  • José Ramón González-Porras
Original Article

Abstract

Eltrombopag is safe and effective in primary chronic ITP. However, lack of clinical trials avoids a clear demonstration of its utility in newly diagnosed and persistent ITP. Our aim here is to report Spanish results for this type of patients. We retrospectively evaluated 220 adult primary ITP patients. According to standard definition, patients were allocated to newly diagnosed (n = 30), persistent (n = 30), and chronic (n = 160) ITP. Groups were homogenous regarding most relevant parameters. 180 (90%) of 220 patients achieved a platelet response (R) with 167 (75.9%) complete responses (CR) after a 15-month follow-up. No statistical significant differences among groups but a trend towards a greater efficacy in newly diagnosed ITP were observed (93.3% of responses with 86.7% of CR). Efficacy in persistent ITP (83.3% of responses with 80.0% of CR) and chronic ITP (79.4% of responses with 73.1% of CR) was similar. 70 patients (31.8%) experienced adverse events. 15 of them were grade 3–4. Most common adverse effects were headache and hepatobiliary laboratory abnormalities (HBLAs). One persistent ITP had a venous thrombosis and one chronic ITP had grade II myelofibrosis. We consider Eltrombopag use for the early stage ITP as effective and safe as it is in chronic ITP.

Keywords

Immune Thrombocytopenia ITP Thrombopoietin TPO 

Supplementary material

12185_2017_2275_MOESM1_ESM.docx (17 kb)
Supplementary material 1 (DOCX 16 kb)

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  • Tomás José González-López
    • 1
  • Fernando Fernández-Fuertes
    • 2
  • José Angel Hernández-Rivas
    • 3
  • Blanca Sánchez-González
    • 4
  • Violeta Martínez-Robles
    • 5
  • María Teresa Alvarez-Román
    • 6
  • Gloria Pérez-Rus
    • 7
  • Cristina Pascual
    • 7
  • Silvia Bernat
    • 8
  • Esther Arrieta-Cerdán
    • 9
  • Carlos Aguilar
    • 10
  • Abelardo Bárez
    • 11
  • María Jesús Peñarrubia
    • 12
  • Pavel Olivera
    • 13
  • Angeles Fernández-Rodríguez
    • 14
  • Erik de Cabo
    • 15
  • Luis Javier García-Frade
    • 16
  • José Ramón González-Porras
    • 17
  1. 1.Department of HematologyHospital Universitario de BurgosBurgosSpain
  2. 2.Department of HematologyHospital Universitario Insular de Gran CanariaLas Palmas De Gran CanariaSpain
  3. 3.Department of HematologyHospital Infanta LeonorMadridSpain
  4. 4.Department of HematologyHospital del MarBarcelonaSpain
  5. 5.Department of HematologyHospital de LeónLeónSpain
  6. 6.Department of HematologyHospital Universitario La PazMadridSpain
  7. 7.Department of HematologyHospital General Universitario Gregorio MarañónMadridSpain
  8. 8.Department of HematologyHospital de La PlanaCastellónSpain
  9. 9.Department of StatisticsHospital Universitario de BurgosBurgosSpain
  10. 10.Department of HematologyHospital de SoriaSoriaSpain
  11. 11.Department of HematologyHospital de AvilaAvilaSpain
  12. 12.Department of HematologyHospital Clínico de ValladolidValladolidSpain
  13. 13.Department of HematologyHospital Universitario Vall de HebronBarcelonaSpain
  14. 14.Department of HematologyHospital Universitario Central de AsturiasOviedoSpain
  15. 15.Department of HematologyHospital del BierzoPonferradaSpain
  16. 16.Department of HematologyHospital Universitario Río HortegaValladolidSpain
  17. 17.Department of HematologyIBSAL-Hospital Universitario de SalamancaSalamancaSpain

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