International Journal of Hematology

, Volume 106, Issue 4, pp 562–572 | Cite as

Efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells for autologous transplantation in Japanese patients with multiple myeloma

  • Masaki Ri
  • Kosei Matsue
  • Kazutaka Sunami
  • Chihiro Shimazaki
  • Akio Hayashi
  • Yoshinori Sunaga
  • Toru Sasaki
  • Kenshi Suzuki
Original Article

Abstract

To evaluate the efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells (HSCs) for autologous transplantation in Japanese patients with multiple myeloma (MM). In a randomized study, patients received G-CSF (filgrastim, 400 µg/m2/day) for 4 days prior to the first dose of plerixafor. Starting on Day 4 evening and for up to 4 days, patients received either plerixafor (240 µg/kg/day) + G-CSF group (PG group) or G-CSF alone (G group). Daily apheresis started on Day 5 for up to 4 days, or until ≥6 × 106 CD34+ cells/kg were collected. A total of 7 patients were randomized in each treatment group. Five patients in PG group and no patients in G group achieved a collection of ≥6 × 106 CD34+ cells/kg in ≤2 days of apheresis [difference of 71.4% (90%CI 29–100%)]. These results were supported by the shorter median time to collect ≥6 × 106 CD34+ cells/kg (2 days in PG group; no patient in G group). The incidence of treatment emergent adverse events (TEAEs) was higher in PG group than in G group. Plerixafor was well tolerated, and effective for the mobilization/collection of peripheral HSCs for autologous transplantation in Japanese patients with MM.

Keywords

Plerixafor G-CSF Multiple myeloma Stem cell Apheresis 

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  1. 1.Department of Hematology and OncologyNagoya City University HospitalNagoyaJapan
  2. 2.Department of Hematology and OncologyKameda Medical CenterChibaJapan
  3. 3.Department of HematologyNational Hospital Organization Okayama Medical CenterOkayamaJapan
  4. 4.Department of HematologyJapan Community Health care Organization Kyoto Kuramaguchi Medical CenterKyotoJapan
  5. 5.Sanofi K.K.TokyoJapan
  6. 6.Department of HematologyJapanese Red Cross Medical CenterTokyoJapan

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