International Journal of Hematology

, Volume 106, Issue 4, pp 581–587 | Cite as

Three cases of relapsed/refractory multiple myeloma under hemodialysis treated with panobinostat/bortezomib/dexamethasone (FVD)

  • Yasunobu Sekiguchi
  • Haruko Takizawa
  • Tadaaki Inano
  • Yasutaka Fukuda
  • Mutsumi Wakabayashi
  • Keiji Sugimoto
  • Shigeki Tomita
  • Hiroshi Izumi
  • Noriko Nakamura
  • Tomohiro Sawada
  • Yasunori Ohta
  • Norio Komatsu
  • Masaaki Noguchi
Case Report

Abstract

Three patients under hemodialysis (HD) with relapsed/refractory multiple myeloma (MM) were administered panobinostat/bortezomib/dexamethasone (FVD). Case 1: The patient was a 66-year-old male with BJP-κ. FVD was effective, but HD could not be discontinued. He developed Grade 3 adverse events (AEs), including nausea, dehydration, and fatigue, following the common terminology criteria for adverse events v4.0. FVD was discontinued after the third course, while HD was continued. Case 2: The patient was a 65-year-old female with IgG-λ + BJP-λ. Amyloidosis was complicated. The first course of FVD was effective, but HD could not be discontinued. She developed G2 AEs, including nausea and fatigue. The cardiac amyloidosis worsened, and she died of heart and renal failure. Case 3: The patient was a 79-year-old male with BJP-κ. FVD was effective, and the HD could be discontinued on day 12 of treatment. No AEs were noted. However, he declined continuation of the FVD and died of MM relapse and renal failure. We analyzed the pharmacokinetics of panobinostat. There were no correlations between dose level and blood level of panobinostat or between blood level, efficacy, and incidence of AEs. We additionally measured the rate of elimination of the drug by HD.

Keywords

Relapsed/refractory multiple myeloma Renal failure Hemodialysis Panobinostat/bortezomib/dexamethasone (FVD) therapy 

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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  • Yasunobu Sekiguchi
    • 1
  • Haruko Takizawa
    • 1
  • Tadaaki Inano
    • 2
  • Yasutaka Fukuda
    • 2
  • Mutsumi Wakabayashi
    • 1
  • Keiji Sugimoto
    • 1
  • Shigeki Tomita
    • 3
  • Hiroshi Izumi
    • 3
  • Noriko Nakamura
    • 4
  • Tomohiro Sawada
    • 4
  • Yasunori Ohta
    • 5
  • Norio Komatsu
    • 2
  • Masaaki Noguchi
    • 1
  1. 1.Department of HematologyJuntendo University Urayasu HospitalUrayasuJapan
  2. 2.Department of HematologyJuntendo University HospitalTokyoJapan
  3. 3.Department of PathologyJuntendo University Urayasu HospitalUrayasuJapan
  4. 4.Department of Clinical LaboratoryJuntendo University Urayasu HospitalUrayasuJapan
  5. 5.Department of Pathology, The Institute of Medical ScienceThe University of TokyoTokyoJapan

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