Skip to main content
SpringerLink
Log in

Interventionelle Therapie von AV-Klappenerkrankungen – Fokus Mitralklappeninsuffizienz

Positionspapier der Deutschen Gesellschaft für Kardiologie

Interventional therapy for AV valve disease—focus on mitral valve regurgitation

Position paper of the German Cardiac Society

  • Positionspapier
  • Published:
Der Kardiologe Aims and scope

Zusammenfassung

Nach der Aortenklappenstenose stellen AV-Klappeninsuffizienzen (AV: atrioventrikular) die häufigsten Herzklappenfehler dar. Ätiologisch unterteilt in primäre und sekundäre Insuffizienzen ist die Behandlungsstrategie grundlegend unterschiedlich. Dies betrifft die Bedeutung und Dauer einer medikamentösen Therapie, den Zeitpunkt einer Intervention, die Frage nach Ersatz oder Rekonstruktion und die Wahl eines chirurgischen oder katheterinterventionellen Verfahrens. Im vergangenen Jahrzehnt hat sich die kathetergestützte Therapie besonders dynamisch entwickelt. So werden inzwischen mehr isolierte Mitralklappeninsuffizienzen mit einem katheterinterventionellen Verfahren behandelt als mittels rekonstruktiver Chirurgie. Auch sind mittlerweile erste kathetergestützte Behandlungen der Trikuspidalklappeninsuffizienz durchgeführt worden. In diesem Positionspapier werden die aktuell zur Verfügung stehenden katheterbasierten Verfahren zur Behandlung der Insuffizienz von Mitral- und Trikuspidalklappe zusammengefasst und ihr gegenwärtiger Stellenwert für die klinische Versorgung dargestellt. In Anbetracht der Prävalenz der Mitralinsuffizienz und der hohen Anzahl von in Deutschland durchgeführten Prozeduren an dieser Klappe hat sich die Deutsche Gesellschaft für Kardiologie entschieden, Qualitätskriterien für eine Zertifizierung von Zentren für die katheterinterventionelle Therapie der Mitralklappe zu definieren.

Abstract

Mitral and tricuspid valve regurgitation remain among the most prevalent valvular defects. The treatment strategy critically depends on the etiology of disease and differs with respect to the role of medical therapy, the timing of intervention, the strategy of whether to replace or repair, and the use of a transcatheter approach. Here, we summarize currently approved transcatheter therapies for the treatment of mitral and tricuspid regurgitation. Given the prevalence of disease and the high and increasing number of transcatheter procedures in particular for mitral valve regurgitation, the German Cardiac Society herewith publishes criteria for centers for transcatheter mitral valve therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Notes

  1. Der einfacheren Lesbarkeit wegen wird auf die explizite Nennung beider Geschlechter verzichtet.

Literatur

  1. 28. Deutscher Herzbericht (2016) ISBN 978-3-9817032-5-2

  2. Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-Bärwolf C, Levang OW, Tornos P, Vanoverschelde J‑L, Vermeer F, Boersma E, Ravaud P, Vahanian A (2003) A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J 24:1231–1243

    Article  PubMed  Google Scholar 

  3. Jones EC, Devereux RB, Roman MJ, Liu JE, Fishman D, Lee ET, Welty TK, Fabsitz RR, Howard BV (2001) Prevalence and correlates of mitral regurgitation in a population-based sample (the Strong Heart Study). Am J Cardiol 87:298–304

    Article  CAS  PubMed  Google Scholar 

  4. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH, Leducq MTN (2015) Mitral valve disease – morphology and mechanisms. Nat Rev Cardiol 12:689–710

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bertrand PB, Schwammenthal E, Levine RA, Vandervoort PM (2017) Exercise dynamics in secondary mitral regurgitation: pathophysiology and therapeutic implications. Circulation 135:297–314

    Article  PubMed  PubMed Central  Google Scholar 

  6. Benfari G, Dandale R, Rossi A, Onorati F, Mugnai G, Ribichini F, Temporelli PL, Vassanelli C (2016) Functional mitral regurgitation: are we treating the real target. J Cardiovasc Med (Hagerstown) 17:767–773

    Article  Google Scholar 

  7. Enriquez-Sarano M, Akins CW, Vahanian A (2009) Mitral regurgitation. Lancet 373:1382–1394

    Article  PubMed  Google Scholar 

  8. Asgar AW, Mack MJ, Stone GW (2015) Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations. J Am Coll Cardiol 65:1231–1248

    Article  PubMed  Google Scholar 

  9. Huttin O, Voilliot D, Mandry D, Venner C, Juillière Y, Selton-Suty C (2016) All you need to know about the tricuspid valve: tricuspid valve imaging and tricuspid regurgitation analysis. Arch Cardiovasc Dis 109:67–80

    Article  PubMed  Google Scholar 

  10. Pozzoli A, De Bonis M, Alfieri O (2016) Mitral valve repair. F1000Res 5

    Google Scholar 

  11. Yanagawa B, Butany J, Verma S (2016) Update on rheumatic heart disease. Curr Opin Cardiol 31:162–168

    Article  PubMed  Google Scholar 

  12. Bouleti C, Juliard JM, Himbert D, Iung B, Brochet E, Urena M, Dilly MP, Ou P, Nataf P, Vahanian A (2016) Tricuspid valve and percutaneous approach: no longer the forgotten valve. Arch Cardiovasc Dis 109:55–66

    Article  PubMed  Google Scholar 

  13. Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR (2015) Mitral annulus calcification. J Am Coll Cardiol 66:1934–1941

    Article  PubMed  Google Scholar 

  14. Barbieri A, Bursi F, Grigioni F, Tribouilloy C, Avierinos JF, Michelena HI, Rusinaru D, Szymansky C, Russo A, Suri R, Bacchi Reggiani ML, Branzi A, Modena MG, Enriquez-Sarano M, Mitral RIDAMIDAI (2011) Prognostic and therapeutic implications of pulmonary hypertension complicating degenerative mitral regurgitation due to flail leaflet: a multicenter long-term international study. Eur Heart J 32:751–759

    Article  PubMed  Google Scholar 

  15. Enriquez-Sarano M, Avierinos J‑F, Messika-Zeitoun D, Detaint D, Capps M, Nkomo V, Scott C, Schaff HV, Tajik AJ (2005) Quantitative determinants of the outcome of asymptomatic mitral regurgitation. N Engl J Med 352:875–883

    Article  CAS  PubMed  Google Scholar 

  16. Ling LH, Enriquez-Sarano M, Seward JB, Tajik AJ, Schaff HV, Bailey KR, Frye RL (1996) Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med 335:1417–1423

    Article  CAS  PubMed  Google Scholar 

  17. Tribouilloy C, Grigioni F, Avierinos JF, Barbieri A, Rusinaru D, Szymanski C, Ferlito M, Tafanelli L, Bursi F, Trojette F, Branzi A, Habib G, Modena MG, Enriquez-Sarano M, Investigators MIDA (2009) Survival implication of left ventricular end-systolic diameter in mitral regurgitation due to flail leaflets a long-term follow-up multicenter study. J Am Coll Cardiol 54:1961–1968

    Article  PubMed  Google Scholar 

  18. Le Tourneau T, Messika-Zeitoun D, Russo A, Detaint D, Topilsky Y, Mahoney DW, Suri R, Enriquez-Sarano M (2010) Impact of left atrial volume on clinical outcome in organic mitral regurgitation. J Am Coll Cardiol 56:570–578

    Article  PubMed  Google Scholar 

  19. Haan CK, Cabral CI, Conetta DA, Coombs LP, Edwards FH (2004) Selecting patients with mitral regurgitation and left ventricular dysfunction for isolated mitral valve surgery. Ann Thorac Surg 78:820–825

    Article  PubMed  Google Scholar 

  20. Grigioni F, Avierinos J‑F, Ling LH, Scott CG, Bailey KR, Tajik AJ, Frye RL, Enriquez-Sarano M (2002) Atrial fibrillation complicating the course of degenerative mitral regurgitation: determinants and long-term outcome. J Am Coll Cardiol 40:84–92

    Article  PubMed  Google Scholar 

  21. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Muñoz DR, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL (2017) 2017 ESC/EACTS Guidelines for the management of valvular heart disease: the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 38(36):2739–2791

    Article  PubMed  Google Scholar 

  22. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O’Gara PT, Rigolin VH, Sundt TM, Thompson A (2017) 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation 35(25):1159–1195

    Article  Google Scholar 

  23. Feldman T, Foster E, Glower DG, Kar S, Rinaldi MJ, Fail PS, Smalling RW, Siegel R, Rose GA, Engeron E, Loghin C, Trento A, Skipper ER, Fudge T, Letsou GV, Massaro JM, Mauri L, Investigators TEVERESTII (2011) Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 364:1395–1406

    Article  CAS  PubMed  Google Scholar 

  24. Feldman T, Kar S, Elmariah S, Smart SC, Trento A, Siegel RJ, Apruzzese P, Fail P, Rinaldi MJ, Smalling RW, Hermiller JB, Heimansohn D, Gray WA, Grayburn PA, Mack MJ, Lim DS, Ailawadi G, Herrmann HC, Acker MA, Silvestry FE, Foster E, Wang A, Glower DD, Mauri L, EVEREST II Investigators (2015) Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5‑year results of EVEREST II. J Am Coll Cardiol 66:2844–2854

    Article  PubMed  Google Scholar 

  25. Maisano F, Franzen O, Baldus S, Schäfer U, Hausleiter J, Butter C, Ussia GP, Sievert H, Richardt G, Widder JD, Moccetti T, Schillinger W (2013) Percutaneous mitral valve interventions in the real world: early and 1‑year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol 62:1052–1061

    Article  PubMed  Google Scholar 

  26. Puls M, Lubos E, Boekstegers P, von Bardeleben RS, Ouarrak T, Butter C, Zuern CS, Bekeredjian R, Sievert H, Nickenig G, Eggebrecht H, Senges J, Schillinger W (2016) One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J 37:703–712

    Article  PubMed  Google Scholar 

  27. Swaans MJ, van den Branden BJL, van der Heyden JAS, Post MC, Rensing BJWM, Eefting FD, Plokker HWM, Jaarsma W (2009) Three-dimensional transoesophageal echocardiography in a patient undergoing percutaneous mitral valve repair using the edge-to-edge clip technique. Eur J Echocardiogr 10:982–983

    Article  CAS  PubMed  Google Scholar 

  28. Giannini C, Fiorelli F, De Carlo M, Guarracino F, Faggioni M, Giordano P, Spontoni P, Pieroni A, Petronio AS (2016) Comparison of percutaneous mitral valve repair versus conservative treatment in severe functional mitral regurgitation. Am J Cardiol 117:271–277

    Article  PubMed  Google Scholar 

  29. Velazquez EJ, Samad Z, Al-Khalidi HR, Sangli C, Grayburn PA, Massaro JM, Stevens SR, Feldman TE, Krucoff MW (2015) The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: a propensity-matched comparison. Am Heart J 170:1050–1059.e3

    Article  PubMed  Google Scholar 

  30. Smith PK, Hung JW, Michler RE (2015) Surgical treatment of moderate ischemic mitral regurgitation. N Engl J Med 372:1773–1774

    Article  PubMed  Google Scholar 

  31. Nishimura RA, Vahanian A, Eleid MF, Mack MJ (2016) Mitral valve disease – current management and future challenges. Lancet 387:1324–1334

    Article  PubMed  Google Scholar 

  32. Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Généreux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP, Mitral VARC (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol 66:278–307

    Article  PubMed  Google Scholar 

  33. Boekstegers P, Hausleiter J, Baldus S, von Bardeleben RS, Beucher H, Butter C, Franzen O, Hoffmann R, Ince H, Kuck KH, Rudolph V, Schäfer U, Schillinger W, Wunderlich N (2013) Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system. Clin Res Cardiol 103(2):85–96

    Article  Google Scholar 

  34. Lin BA, Forouhar AS, Pahlevan NM, Anastassiou CA, Grayburn PA, Thomas JD, Gharib M (2010) Color Doppler jet area overestimates regurgitant volume when multiple jets are present. J Am Soc Echocardiogr 23:993–1000

    Article  PubMed  Google Scholar 

  35. Lang RM, Badano LP, Tsang W, Adams DH, Agricola E, Buck T, Faletra FF, Franke A, Hung J, de Isla LP, Kamp O, Kasprzak JD, Lancellotti P, Marwick TH, McCulloch ML, Monaghan MJ, Nihoyannopoulos P, Pandian NG, Pellikka PA, Pepi M, Roberson DA, Shernan SK, Shirali GS, Sugeng L, Ten Cate FJ, Vannan MA, Zamorano JL, Zoghbi WA, Echocardiography EAO (2012) EAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography. J Am Soc Echocardiogr 25:3–46

    Article  PubMed  Google Scholar 

  36. Alessandrini H, Kreidel F, Schlüter M, Frerker C, Schmidt T, Thielsen T, Schäfer U, Kuck KH (2017) Prognostic implication of post-MitraClip vena contracta area in heart-failure patients with functional mitral regurgitation. EuroIntervention 12(16):1946–1953

    Article  PubMed  Google Scholar 

  37. Gaemperli O, Biaggi P, Gugelmann R, Osranek M, Schreuder JJ, Bühler I, Sürder D, Lüscher TF, Felix C, Bettex DA, Grünenfelder J, Corti R (2013) Real-time left ventricular pressure: volume loops during percutaneous mitral valve repair with the MitraClip system. Circulation 127(9):1018–1027

    Article  PubMed  Google Scholar 

  38. Horstkotte J, Kloeser C, Beucher H, Schwarzlaender E, von Bardeleben RS, Boekstegers P (2016) Intraprocedural assessment of mitral regurgitation during the mitraclip procedure: Impact of continuous left atrial pressure monitoring. Catheter Cardiovasc Interv 88:1134–1143

    Article  PubMed  Google Scholar 

  39. Feldman T, Wasserman HS, Herrmann HC, Gray W, Block PC, Whitlow P, Goar FSt, Rodriguez L, Silvestry F, Schwartz A, Sanborn TA, Condado JA, Foster E (2005) Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial. J Am Coll Cardiol 46:2134–2140

    Article  PubMed  Google Scholar 

  40. Feldman T, Kar S, Rinaldi M, Fail P, Hermiller J, Smalling R, Whitlow PL, Gray W, Low R, Herrmann HC, Lim S, Foster E, Glower D, Investigators EVEREST (2009) Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 54:686–694

    Article  PubMed  Google Scholar 

  41. Maisano F, Taramasso M, Nickenig G, Hammerstingl C, Vahanian A, Messika-Zeitoun D, Baldus S, Huntgeburth M, Alfieri O, Colombo A, La Canna G, Agricola E, Zuber M, Tanner FC, Topilsky Y, Kreidel F, Kuck K‑H (2015) Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J 37(10):817–825

    Article  PubMed  Google Scholar 

  42. Schofer J, Siminiak T, Haude M, Herrman JP, Vainer J, Wu JC, Levy WC, Mauri L, Feldman T, Kwong RY, Kaye DM, Duffy SJ, Tübler T, Degen H, Brandt MC, Van Bibber R, Goldberg S, Reuter DG, Hoppe UC (2009) Percutaneous mitral annuloplasty for functional mitral regurgitation: results of the CARILLON Mitral Annuloplasty Device European Union Study. Circulation 120:326–333

    Article  PubMed  PubMed Central  Google Scholar 

  43. Siminiak T, Wu JC, Haude M, Hoppe UC, Sadowski J, Lipiecki J, Fajadet J, Shah AM, Feldman T, Kaye DM, Goldberg SL, Levy WC, Solomon SD, Reuter DG (2012) Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN Trial. Eur J Heart Fail 14:931–938

    Article  PubMed  PubMed Central  Google Scholar 

  44. Kiefer P, Seeburger J (2017) The potential of transapical beating-heart mitral valve repair with neo-chordae. Ann Transl Med 5(1):9. https://doi.org/10.21037/atm.2017.01.08

    Article  PubMed  PubMed Central  Google Scholar 

  45. Gammie JS, Wilson P, Bartus K, Gackowski A, Hung J, D’Ambra MN, Kolsut P, Bittle GJ, Szymanski P, Sadowski J, Kapelak B, Bilewska A, Kusmierczyk M, Ghoreishi M (2016) Transapical beating-heart mitral valve repair with an expanded polytetrafluoroethylene cordal implantation device: initial clinical experience. Circulation 134:189–197

    Article  CAS  PubMed  Google Scholar 

  46. Bouleti C, Fassa A‑A, Himbert D, Brochet E, Ducrocq G, Nejjari M, Ghodbane W, Depoix J‑P, Nataf P, Vahanian A (2015) Transfemoral implantation of transcatheter heart valves after deterioration of mitral bioprosthesis or previous ring annuloplasty. Jacc Cardiovasc Interv 8:83–91

    Article  PubMed  Google Scholar 

  47. Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O’Hair D, Dumonteil N, Rodés-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinho JJ, Attizzani GF, George I, Nickenig G, Fassa A‑A, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, O’Neill W (2016) Transcatheter mitral valve replacement in native mitral valve disease with severe mitral annular calcification: results from the first multicenter global registry. Jacc Cardiovasc Interv 9:1361–1371

    Article  PubMed  Google Scholar 

  48. Paradis J‑M, Del Trigo M, Puri R, Rodés-Cabau J (2015) Transcatheter valve-in-valve and valve-in-ring for treating aortic and mitral surgical prosthetic dysfunction. J Am Coll Cardiol 66:2019–2037

    Article  PubMed  Google Scholar 

  49. Seiffert M, Conradi L, Baldus S, Schirmer J, Knap M, Blankenberg S, Reichenspurner H, Treede H (2012) Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses. Jacc Cardiovasc Interv 5:341–349

    Article  PubMed  Google Scholar 

  50. Ye J, Cheung A, Yamashita M, Wood D, Peng D, Gao M, Thompson CR, Munt B, Moss RR, Blanke P, Leipsic J, Dvir D, Webb JG (2015) Transcatheter aortic and mitral valve-in-valve implantation for failed surgical bioprosthetic valves: an 8‑year single-center experience. Jacc Cardiovasc Interv 8:1735–1744

    Article  PubMed  Google Scholar 

  51. Dvir D (2012) TAVI for degenerative bioprosthetic surgical valves: results of the Global Valve-in-Valve registry. Presented at: EuroPCR. EuroPCR. Paris, France

    Google Scholar 

  52. Muller DW, Farivar RS, Jansz P, Bae R, Walters D, Clarke A, Grayburn PA, Stoler RC, Dahle G, Rein KA, Shaw M, Scalia GM, Guerrero M, Pearson P, Kapadia S, Gillinov M, Pichard A, Corso P, Popma J, Chuang M, Blanke P, Leipsic J, Sorajja P, Tendyne GFTI (2017) Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial. J Am Coll Cardiol 69:381–391

    Article  PubMed  Google Scholar 

  53. Blackstone EH, Suri RM, Rajeswaran J, Babaliaros V, Douglas PS, Fearon WF, Miller DC, Hahn RT, Kapadia S, Kirtane AJ, Kodali SK, Mack M, Szeto WY, Thourani VH, Tuzcu EM, Williams MR, Akin JJ, Leon MB, Svensson LG (2015) Propensity-matched comparisons of clinical outcomes after transapical or transfemoral transcatheter aortic valve replacement: a placement of aortic transcatheter valves (PARTNER)-I trial substudy. Circulation 131:1989–2000

    Article  PubMed  Google Scholar 

  54. Frerker C, Schmidt T, Schlüter M, Bader R, Schewel J, Schewel D, Thielsen T, Kreidel F, Alessandrini H, Schlingloff F, Schäfer U, Kuck KH (2016) Transcatheter implantation of aortic valve prostheses into degenerated mitral valve bioprostheses and failed annuloplasty rings: outcomes according to access route and Mitral Valve Academic Research Consortium (MVARC) criteria. EuroIntervention 12:1520–1526

    Article  PubMed  Google Scholar 

  55. Topilsky Y, Khanna AD, Oh JK, Nishimura RA, Enriquez-Sarano M, Jeon YB, Sundt TM, Schaff HV, Park SJ (2011) Preoperative factors associated with adverse outcome after tricuspid valve replacement. Circulation 123:1929–1939

    Article  PubMed  Google Scholar 

  56. Nath J, Foster E, Heidenreich PA (2004) Impact of tricuspid regurgitation on long-term survival. J Am Coll Cardiol 43:405–409

    Article  PubMed  Google Scholar 

  57. Koelling TM, Aaronson KD, Cody RJ, Bach DS, Armstrong WF (2002) Prognostic significance of mitral regurgitation and tricuspid regurgitation in patients with left ventricular systolic dysfunction. Am Heart J 144:524–529

    Article  PubMed  Google Scholar 

  58. Hahn RT, Zamorano JL (2017) The need for a new tricuspid regurgitation grading scheme. Eur Heart J Cardiovasc Imaging 18:1342–1343

    Article  PubMed  Google Scholar 

  59. Rodés-Cabau J, Taramasso M, O’Gara PT (2016) Diagnosis and treatment of tricuspid valve disease: current and future perspectives. Lancet 388(10058):2431–2442

    Article  PubMed  Google Scholar 

  60. Lauten A, Doenst T, Hamadanchi A, Franz M, Figulla HR (2014) Percutaneous bicaval valve implantation for transcatheter treatment of tricuspid regurgitation: clinical observations and 12-month follow-up. Circ Cardiovasc Interv 7:268–272

    Article  PubMed  Google Scholar 

  61. Kapadia SR, Krishnaswamy A, Tuzcu EM (2017) Percutaneous therapy for tricuspid regurgitation: a new frontier for interventional cardiology. Circulation 135(19):1815–1818

    Article  PubMed  Google Scholar 

  62. Nickenig G, Kowalski M, Hausleiter J, Braun D, Schofer J, Yzeiraj E, Rudolph V, Friedrichs K, Maisano F, Taramasso M, Fam NP, Bianchi G, Bedogni F, Denti P, Alfieri O, Latib A, Colombo A, Hammerstingl C, Schueler R (2017) Transcatheter treatment of severe tricuspid regurgitation with the edge-to-edge: mitraclip technique. Circulation 135(19):1802–1814

    Article  PubMed  Google Scholar 

  63. Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Richtlinie zu minimalinvasiven Herzklappeninterventionen: Erstfassung. BAnz AT 24. Juli 2015

  64. Schächinger V, Nef H, Achenbach S, Butter C et al (2015) Arbeitsanweisung in Herzkatheterlabor und Hybridoperationssaal. Kardiologe 9:29–34

    Article  Google Scholar 

  65. Boekstegers P, Hausleiter J, Baldus S, Bardeleben RS, Beucher H, Butter C, Franzen O, Hoffmann R, Ince H, Kuck KH, Rudolph V, Schäfer U, Schillinger W, Wunderlich N (2013) Interventionelle Behandlung der Mitralklappeninsuffizienz mit dem MitraClip®-Verfahren. Kardiologe 7:91–104

    Article  Google Scholar 

  66. Kuck K‑H, Eggebrecht H, Elsässer A, Hamm C, Haude M, Ince H, Katus H, Möllmann H, Naber CK, Schunkert H, Thiele H, Werner N (2016) Qualitätskriterien zur Durchführung der kathetergestützten Aortenklappenimplantation (TAVI). Kardiologe 10:282–300

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Kardiologie, Angiologie, Pneumologie und Internistische Intensivmedizin, Herzzentrum der Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland

    S. Baldus

  2. Herzzentrum Siegburg, Klinik für Kardiologie, Angiologie, HELIOS Klinikum Siegburg, Siegburg, Deutschland

    P. Boekstegers

  3. Medizinisches Versorgungszentrum, CCB am AGAPLESION BETHANIEN KRANKENHAUS, Frankfurt am Main, Deutschland

    H. Eggebrecht

  4. Klinik für Kardiologie, Klinikum Oldenburg AöR, Oldenburg, Deutschland

    A Elsässer

  5. Medizinische Klinik und Poliklinik I, LMU Klinikum der Universität München, München, Deutschland

    J. Hausleiter

  6. Klinik für Innere Medizin, Kardiologie und konservative Intensivmedizin, Vivantes Klinikum Am Urban, Berlin, Deutschland

    H. Ince

  7. Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    M. Kelm

  8. Kardiologie, Asklepios Klinik St. Georg, Hamburg, Deutschland

    K. H. Kuck

  9. Klinik für Innere Medizin I, St.-Johannes-Hospital Dortmund, Dortmund, Deutschland

    H. Möllmann

  10. Medizinische Klinik I – Kardiologie und Angiologie, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Deutschland

    H. Nef

  11. Klinik für Kardiologie, Angiologie, Pneumologie und Internistische Intensivmedizin, Herzzentrum der Universität zu Köln, Köln, Deutschland

    V. Rudolph

  12. Klinikum Mitte, Klinik für Kardiologie und internistische Intensivmedizin, Klinikum Bielefeld gem. GmbH, Bielefeld, Deutschland

    C. Stellbrink

  13. Medizinische Klinik und Poliklinik II, Klinik für Kardiologie, Angiologie und internistische Intensivmedizin, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland

    S. v. Bardeleben

  14. Klinik für Innere Medizin II, Universitätsklinikum Ulm, Ulm, Deutschland

    J. Wöhrle

Authors
  1. S. Baldus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. H. Kuck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Rudolph
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Nef
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Eggebrecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Boekstegers
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Wöhrle
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. H. Ince
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H. Möllmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. C. Stellbrink
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J. Hausleiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. S. v. Bardeleben
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. M. Kelm
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. A Elsässer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Baldus.

Ethics declarations

Interessenkonflikt

Den Interessenkonflikt der Autoren S. Baldus, K.H. Kuck, V. Rudolph, H. Nef, H. Eggebrecht, P. Boekstegers, J. Wöhrle, H. Ince, H. Möllmann, C. Stellbrink, J. Hausleiter, S. v. Bardeleben, M. Kelm und A. Elsässer finden Sie online auf der DGK-Homepage unter http://leitlinien.dgk.org/ bei der entsprechenden Publikation.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baldus, S., Kuck, K.H., Rudolph, V. et al. Interventionelle Therapie von AV-Klappenerkrankungen – Fokus Mitralklappeninsuffizienz. Kardiologe 12, 128–144 (2018). https://doi.org/10.1007/s12181-018-0232-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12181-018-0232-y

Schlüsselwörter

Keywords

Search

Navigation