Abstract
In this research, a reproducible surface plasmon resonance (SPR) immunosensor based on inhibition format was fabricated for stable and sensitive detection of four sulfonamides (SAs) in animal-derived foods. The parameters in the fabrication and measurement process were optimized and discussed in details. The method using the proposed SPR immunosensor was validated and exhibited favorable performance for SAs residues detection in common animal-derived food products, as well as acceptable accuracy (pure milk 88.5–106.2%; egg 89.0–91.5%; chicken muscle 87.2–94.7%; beef 84.8–96.9%; fish 87.8–95.0%), precision (relative standard deviation (n = 3), pure milk 3.2–5.2%; egg 1.1–5.4%; chicken muscle 1.1–5.9%; beef 2.5–7.1%; fish 4.6–5.3%), and sensitivity (IC15, pure milk 59.6 ng mL−1, egg 56.1 ng mL−1, chicken muscle 66.9 ng mL−1, beef 63.3 ng mL−1, fish 62.7 ng mL−1 ). Each detection cycle could finish in less than 5 min, and each SPR chip could reuse 300 analysis cycles with response attenuation of 3.7%. These results have demonstrated that the proposed SPR immunosensor has offered an effective, accurate, sensitive, rapid, and low-cost methodology for SAs residue detection in food sample, and this method has great potential for the routine analysis of large numbers of samples on measuring different kinds of compounds.
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References
Abadian PN, Kelley CP, Goluch ED (2014) Cellular analysis and detection using surface plasmon resonance techniques. Anal Chem 86(6):2799–2812
Adrian J, Font H, Diserens JM, Sanchez-Baeza F, Marco MP (2009) Generation of broad specificity antibodies for sulfonamide antibiotics and development of an enzyme-linked immunosorbent assay (ELISA) for the analysis of milk samples. J Agric Food Chem 57(2):385–394
Agrawa H, Shrivastav MA, Gupta BD (2016) Surface plasmon resonance based optical fiber sensor for atrazine detection using molecular imprinting technique. Sensor Actuat B-Chem 227:204–211
Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G, Tell L, Gehring R, Davis J, Riviere JE (2016) Health concerns and management of select veterinary drug residues. Food Chem Toxicol 88:112–122
Bousova K, Senyuva H, Mittendorf K (2013) Quantitative multi-residue method for determination antibiotics in chicken meat using turbulent flow chromatography coupled to liquid chromatography-tandem mass spectrometry. J Chromatogr A 1274(2):19–27
Campbell WC (2008) History of the discovery of sulfaquinoxaline as a coccidiostat. J Parasitol 94(4):934–945
Ceruso M, Prete SD, AlOthman Z, Osman SM, Scozzafava A, Capasso C, Supuran CT (2014) Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis gamma-carbonic anhydrase. Bioorg Med Chem Lett 24(16):4006–4010
Chen YQ, Chen Q, Han MM, Liu JY, Zhao P, He LD, Zhang Y, Niu YM, Yang WJ, Zhang LY (2016) Near-infrared fluorescence-based multiplex lateral flow immunoassay for the simultaneous detection of four antibiotic residue families in milk. Biosens Bioelectron 79:430–434
European Union (2002) Commission Decision 2002/657/EC implementing Council Directive 96/23/EC concerning the performance of analytical methods and interpretation of results. Off J Eur Union 221:8–36
Fang GZ, He JX, Wang S (2006) Multiwalled carbon nanotubes as sorbent for on-line coupling of solid-phase extraction to high-performance liquid chromatography for simultaneous determination of 10 sulfonamides in eggs and pork. J Chromatogr A 1127(1–2):12–17
Frenich GA, Romero-Gonzalez R, Aguilera-Luiz MDM (2014) Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS. TRAC-Trend Anal Chem 63:158–169
Jiang W, Beloglazova NV, Wang Z, Jiang H, Wen K, de Saeger S, Luo P, Wu Y, Shen J (2014) Development of a multiplex flow-through immunoaffinity chromatography test for the on-site screening of 14 sulfonamide and 13 quinolone residues in milk. Biosens Bioelectron 66:124–128
Jorn CC, Edward PC (2005) Interaction of ochratoxin A with molecularly imprinted polypyrrole film on surface plasmon resonance sensor. React Funct Polym 63:171–176
Kung TA, Tsai CW, Ku BC, Wang WH (2015) A generic and rapid strategy for determining trace multiresidues of sulfonamides in aquatic products by using an improved QuEChERS method and liquid chromatography–electrospray quadrupole tandem mass spectrometry. Food Chem 175C:189–196
Li YZ, Wu XW, Li ZQ, Zhong SX, Wang WP, Wang AJ, Chen JR (2015) Fabrication of CoFe2O4-graphene nanocomposite and its application in the magnetic solid phase extraction of sulfonamides from milk samples. Talanta 144:1279–1286
Liang GL, Luo ZW, Liu KP, Wang YM, Dai JX, Duan YX (2016) Fiber optic surface plasmon resonance-based biosensor technique: fabrication, advancement, and application. Crit Rev Anal Chem 46(3):213–223
Lu Y, Xia YQ, Pan MF, Wang XJ, Wang S (2014) Development of a surface plasmon resonance immunosensor for detecting melamine in milk products and pet foods. J Agric Food Chem 62(51):12471–12476
Luz JGG, Souto DEP, Machado-Assis GF, Lana M, Kubota LT, Luz RCS, Damos FS, Martins HR (2015) Development and evaluation of a SPR-based immunosensor for detection of anti-Trypanosoma cruzi antibodies in human serum. Sensor Actuat B-Chem 212:287–296
Mauriz E, García-Fernández MC, Lechuga LM (2016) Towards the design of universal immunosurfaces for SPR-based assays: a review. TRAC-Trend in Anal Chem 79:191–198
Mendoza JHD, Maggi L, Bonetto L, Carmena BR, Lezana A, Mocholí FA, Carmona M (2012) Validation of antibiotics in catfish by on-line solid phase extraction coupled to liquid chromatography tandem mass spectrometry. Food Chem 134(2):1149–1155
Mine N, Onodera T, Tahara Y, Umino K, Toko K (2013) Detection of surfactants using surface plasmon resonance sensor for screening of pesticide residue. IEEJ Trans Sens Micro 133(1):14–19
Mohseni S, Moghadam TT, Dabirmanesh B, Jabbari S, Khajeh K (2016) Development of a label-free SPR sensor for detection of matrixmetalloproteinase-9 by antibody immobilization on carboxymethyldextran chip. Biosens Bioelectron 81:510–516
Onodera T, Toko K (2014) Towards an electronic dog nose: surface plasmon resonance immunosensor for security and safety. Sensors 14(9):16586–16616
Senyuva HZ, Gilbert J (2010) Immunoaffinity column clean-up techniques in food analysis: a review. J Chromatogr B 878(2):115–132
Souto DEP, Fonseca AM, Barragan JTC, Luz RDS, Andrade HM, Damos FS, Kubota LT (2015) SPR analysis of the interaction between a recombinant protein of unknown function in Leishmania infantum immobilised on dendrimers and antibodies of the visceral leishmaniasis: a potential use in immunodiagnosis. Biosens Bioelectron 70:275–281
Suherman, Morita K, Kawaguchi T (2015) Highly selective and sensitive detection of β-agonists using a surface plasmon resonance sensor based on an alkanethiol monolayer functionalized on a Au surface. Biosens Bioelectron 67: 356–363
Suherman, Morita K, Kawaguchi T (2016) Surface plasmon resonance sensor using functionalized alkanethiols monolayer for illegal compound detection. J Nonlinear Optic Phys Mat 25:1650007
Takino M, Yamaguchi K, Nakahara T (2004) Determination of carbamate pesticide residues in vegetables and fruits by liquid chromatography-atmospheric pressure photoionization-mass spectrometry and atmospheric pressure chemical ionization-mass spectrometry. J Agric Food Chem 52(4):727–735
Tetzner NF, Maniero MG, Rodrigues-Silva C, Rath S (2016) On-line solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry as a powerful technique for the determination of sulfonamide residues in soils. J Chromatogr A 1452:89–97
Xu Y, Ding J, Chen HY, Zhao Q, Hou J, Yan J, Wang H, Ding L, Ren NQ (2013) Fast determination of sulfonamides from egg samples using magnetic multiwalled carbon nanotubes as adsorbents followed by liquid chromatography-tandem mass spectrometry. Food Chem 134(2):1149–1155
Xue Q, Qi Y, Liu F (2015) Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters. Environ Sci Pollut Res 22(s 1–2):16857–16867
Zhang HY, Duan ZJ, Wang L, Zhang Y, Wang S (2006) Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays. J Agric Food Chem 54(13):4499–4505
Acknowledgements
This work is financially supported by the National Natural Science Foundation of China (Project No. 31301461 and 31501566), the International Science and Technology Cooperation Program of China (Project No. 2014DFR30350), and the program for Changjiang Scholars and Innovative Research Team in University (IRT1166).
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Mingfei Pan declares that he has no conflict of interest. Xiaojun Wang declares that she has no conflict of interest. Junping Wang declares that he has no conflict of interest. Yang Lu declares that she has no conflict of interest. Kun Qian declares that she has no conflict of interest. Shuo Wang declares that he has no conflict of interest.
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All applicable international, national, and institutional guidelines for the care and use of animals were followed.
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Pan, M., Wang, X., Wang, J. et al. Stable and Sensitive Detection of Sulfonamide Residues in Animal-Derived Foods Using a Reproducible Surface Plasmon Resonance Immunosensor. Food Anal. Methods 10, 2027–2035 (2017). https://doi.org/10.1007/s12161-016-0752-7
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DOI: https://doi.org/10.1007/s12161-016-0752-7