Food Analytical Methods

, Volume 10, Issue 6, pp 1817–1825 | Cite as

Surfactant-Alumina-Coated Magnetic Nanoparticles as an Efficient Aldehydes Adsorbent Prior Their Determination by HPLC



Separation and determination of trace levels of low-molecular weight aldehydes are very important from water suppliers’ point of view. Modified magnetic nanoparticles can be used for this propose. Alumina-coated magnetic nanoparticles modified with sodium dodecyl sulfate (SDS/Al2O3/Fe3O4) are used for extraction of formaldehyde (FA) and acetaldehyde (AA) from drinking water samples. In this manner, the aldehydes were converted to their corresponding hydrazones by the reaction with 2,4-dinitrophenylhydrazine (DNPH). After preconcentration, the HPLC technique was used for the determination of the aldehydes and the results were compared with the commercial C18 solid-phase extraction (SPE) columns. The results showed that the extraction with SDS/Al2O3/Fe3O4 is more efficient and faster than the commercial columns. A very good repeatability (RSD was 3.3 and 2.4% for FA and AA, respectively, n = 7, C = 50 ppb) was obtained. Linear regression analysis indicated that the responses for two investigated compounds were linear over about two orders of magnitude above the LOD (LOD was 3.6 ppb for FA and 3.2 ppb for AA), with correlation coefficients >0.9990. Determination of FA and AA in tap water and various brands of bottled waters were carried out using the modified nanoparticles. Based on the obtained results, the aldehyde content of the commercial bottled waters was particularly apparent after exposure to direct sunlight.


Aldehydes Bottled water HPLC Magnetic nanoparticles Surfactants Tap water 


Compliance with Ethical Standards

Conflict of Interest

Mrs. Ahmadi, an MSc student, declares that she has no conflict of interest. Dr. Akbar Malekpour declares that he has no conflict of interest. During this project, he was an employee of the University of Isfahan.

Ethical Approval

In this study, all applicable international, national, and/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.

Informed Consent

Not applicable.


  1. Bagheban Shahri F, Niazi A (2015) Synthesis of modified maghemite nanoparticles and its application for removal of Acridine Orange from aqueous solutions by using Box-Behnken design. J Magn Magn Mater 396:318–326. doi: 10.1016/j.jmmm.2015.08.054 CrossRefGoogle Scholar
  2. Ballesteros-Gomez A, Rubio S (2009) Hemimicelles of alkyl carboxylates chemisorbed onto magnetic nanoparticles: study and application to the extraction of carcinogenic polycyclic aromatic hydrocarbons in environmental water samples. Anal Chem 81:9012–9020CrossRefGoogle Scholar
  3. Banos C-E, Silva M (2009a) In situ continuous derivatization/pre-concentration of carbonyl compounds with 2,4-dinitrophenylhydrazine in aqueous samples by solid-phase extraction: application to liquid chromatography determination of aldehydes. Talanta 77:1597–1602CrossRefGoogle Scholar
  4. Banos CE, Silva M (2009b) Comparison of several sorbents for continuous in situ derivatization and preconcentration of low-molecular mass aldehydes prior to liquid chromatography-tandem mass spectrometric determination in water samples. J Chromatogr A 1216:6554–6559CrossRefGoogle Scholar
  5. Basheer C, Pavagadhi S, Yu H, Balasubramanian R, Lee HK (2010) Determination of aldehydes in rainwater using micro-solid-phase extraction and high-performance liquid chromatography. J Chromatogr A 1217:6366–6372. doi: 10.1016/j.chroma.2010.08.012 CrossRefGoogle Scholar
  6. Bojdi MK, Behbahani M, Hesam G, Mashhadizadeh MH (2016) Application of magnetic lamotrigine-imprinted polymer nanoparticles as an electrochemical sensor for trace determination of lamotrigine in biological samples RSC. Advances 6:32374–32380. doi: 10.1039/C6RA02096H Google Scholar
  7. Costi EM, Goryacheva I, Sicilia MD, Rubio S, Perez-Bendito D (2008) Supramolecular solid-phase extraction of ibuprofen and naproxen from sewage based on the formation of mixed supramolecular aggregates prior to their liquid chromatographic/photometric determination. J Chromatogr A 1210:1–7. doi: 10.1016/j.chroma.2008.09.024 CrossRefGoogle Scholar
  8. Faraji M, Yamini Y, Rezaee M (2010) Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization, and applications. J Iran Chem Soc 7:1–37CrossRefGoogle Scholar
  9. Fung K, Grosjean D (1981) Determination of nanogram amounts of carbonyls as 2,4-dinitrophenylhydrazones by high performance liquid chromatography. Anal Chem 53:168–171CrossRefGoogle Scholar
  10. Giokas DL, Tsogas GZ, Vlessidis AG (2009) On-line derivatization coupled to flow injection permanganate chemiluminescence detection of total carbonyl compounds in natural waters and drinking water. Anal Chim Acta 651:188–195CrossRefGoogle Scholar
  11. Goldberg S, Johnston CT (2001) Mechanisms of arsenic adsorption on amorphous oxides evaluated using macroscopic measurements, vibrational spectroscopy, and surface complexation modeling. J Colloid Interface Sci 234:204–216CrossRefGoogle Scholar
  12. Hasanzadeh M, Pournaghi-Azar MH, Shadjou N, Jouyban A (2014) Magnetic nanoparticles incorporated on functionalized mesoporous silica: an advanced electrochemical sensor for simultaneous determination of amiodarone and atenolol. RSC Advances 4:4710–4717. doi: 10.1039/C3RA45433A CrossRefGoogle Scholar
  13. Hashemi M, Taherimaslak Z, Parvizi S, Torkejokar M (2014) Spectrofluorimetric determination of zearalenone using dispersive liquid-liquid microextraction coupled to micro-solid phase extraction onto magnetic nanoparticles. RSC Advances 4:45065–45073. doi: 10.1039/C4RA07684B CrossRefGoogle Scholar
  14. Hu C, Jia L, Liu Q, Zhang S (2010) Development of magnetic octadecylsilane particles as solid-phase extraction adsorbent for the determination of fat-soluble vitamins in fruit juice-milk beverage by capillary liquid chromatography. J Sep Sci 33:2145–2152CrossRefGoogle Scholar
  15. Huang W et al (2013) Highly sensitive formaldehyde sensors based on polyvinylamine modified polyacrylonitrile nanofibers. RSC Advances 3:22994–23000. doi: 10.1039/C3RA44671A CrossRefGoogle Scholar
  16. Kieber RJ, Mopper K (1990) Determination of picomolar concentrations of carbonyl compounds in natural waters, including seawater, by liquid chromatography. Environ Sci Technol 24:1477–1481CrossRefGoogle Scholar
  17. Kim HJ, Shin HS (2011) Simple and automatic determination of aldehydes and acetone in water by headspace solid-phase microextraction and gas chromatography-mass spectrometry. J Sep Sci 34:693–699CrossRefGoogle Scholar
  18. Kosmulski M (2009) pH-dependent surface charging and points of zero charge. IV. Update and new approach. J Colloid Interface Sci 337:439–448. doi: 10.1016/j.jcis.2009.04.072 CrossRefGoogle Scholar
  19. Lin Y-L, Wang P-Y, Hsieh L-L, Ku K-H, Yeh Y-T, Wu C-H (2009) Determination of linear aliphatic aldehydes in heavy metal containing waters by high-performance liquid chromatography using 2,4-dinitrophenylhydrazine derivatization. J Chromatogr A 1216:6377–6381CrossRefGoogle Scholar
  20. Lui S, Wehmschulte RJ, Burba CM (2003) Synthesis of novel nanostructured γ-Al2O3 by pyrolysis of aluminiumoxyhydride-HAlO. J Mater Chem 13:3107–3111CrossRefGoogle Scholar
  21. Lv G et al (2008) Novel nanocomposite of nano Fe 3O 4 and polylactide nanofibers for application in drug uptake and induction of cell death of leukemia cancer cells. Langmuir 24:2151–2156CrossRefGoogle Scholar
  22. Matatagui D, Kolokoltsev OV, Qureshi N, Mejia-Uriarte EV, Saniger JM (2015) A magnonic gas sensor based on magnetic nanoparticles. Nanoscale 7:9607–9613. doi: 10.1039/C5NR01499A CrossRefGoogle Scholar
  23. Nawrocki J, Kalkowska I, Dabrowska A (1996) Optimization of solid-phase extraction method for analysis of low-ppb amounts of aldehydes-ozonation by-products. J Chromatogr A 749:157–163CrossRefGoogle Scholar
  24. Neng NR, Nogueira JMF (2010) Determination of short-chain carbonyl compounds in drinking water matrices by bar adsorptive micro-extraction (BAμE) with in situ derivatization. Anal Bioanal Chem 398:3155–3163CrossRefGoogle Scholar
  25. Ogawa IS, Fritz J (1985) Determination of low concentrations of low-molecular-weight aldehydes and ketones in aqueous samples. J Chromatogr A 329:81–89CrossRefGoogle Scholar
  26. Ozlem KE (2008) Acetaldehyde migration from polyethylene terephthalate bottles into carbonated beverages in Türkiye. Int J Food Sci Technol 43:333–338Google Scholar
  27. Pang X, Mu Y (2006) Seasonal and diurnal variations of carbonyl compounds in Beijing ambient air. Atmos Environ 40:6313–6320CrossRefGoogle Scholar
  28. Rosenberger W, Beckmann B, Wrbitzky R (2016) Airborne aldehydes in cabin-air of commercial aircraft: measurement by HPLC with UV absorbance detection of 2,4-dinitrophenylhydrazones. J Chromatogr B. doi: 10.1016/j.jchromb.2015.08.046 Google Scholar
  29. Sun L, Zhang C, Chen L, Liu J, Jin H, Xu H, Ding L (2009) Preparation of alumina-coated magnetite nanoparticle for extraction of trimethoprim from environmental water samples based on mixed hemimicelles solid-phase extraction. Anal Chim Acta 638:162–168CrossRefGoogle Scholar
  30. Takeda K, Katoh S, Nakatani N, Sakugawa H (2006) Rapid and highly sensitive determination of low-molecular-weight carbonyl compounds in drinking water and natural water by preconcentration HPLC with 2,4-dinitrophenylhydrazine. Anal Sci 22:1509–1514CrossRefGoogle Scholar
  31. Tan CJ, Chua HG, Ker KH, Tong YW (2008) Preparation of bovine serum albumin surface-imprinted submicrometer particles with magnetic susceptibility through core-shell miniemulsion polymerization. Anal Chem 80:683–692. doi: 10.1021/ac701824u CrossRefGoogle Scholar
  32. Tian M-m, Chen D-X, Sun Y-L, Yang Y-W, Jia Q (2013) Pillararene-functionalized Fe3O4 nanoparticles as magnetic solid-phase extraction adsorbent for pesticide residue analysis in beverage samples. RSC Advances 3:22111–22119. doi: 10.1039/C3RA43752C CrossRefGoogle Scholar
  33. Tsai CF, Shiau HW, Lee SC, Chou SS (2003) Determination of low-molecule-weight aldehydes in packed drinking water by high performance liquid chromatography. J Food Drug Anal 11:46–52Google Scholar
  34. Vakros J, Kordulis C, Lycourghiotis A (2002) Potentiometric mass titrations: a quick scan for determining the point of zero charge. Chem Commun 8:1980–1981CrossRefGoogle Scholar
  35. Wardencki W, Sowiski P, Curyo J (2003) Evaluation of headspace solid-phase microextraction for the analysis of volatile carbonyl compounds in spirits and alcoholic beverages. J Chromatogr A 984:89–96CrossRefGoogle Scholar
  36. Whittle PJ, PJ R (1988) Determination of formaldehyde in river water by high-performance liquid chromatography. Analyst 113:665–666CrossRefGoogle Scholar
  37. Xu J-K, Zhang F-F, Sun J-J, Sheng J, Wang F, Sun M (2014) Bio and nanomaterials based on Fe3O4. Molecules 19:21506CrossRefGoogle Scholar
  38. Zargar B, Parham H, Hatamie A (2009) Modified iron oxide nanoparticles as solid phase extractor for spectrophotometeric determination and separation of basic fuchsin. Talanta 77:1328–1331CrossRefGoogle Scholar
  39. Zhang L, Liu B, Dong S (2007a) Bifunctional nanostructure of magnetic core luminescent shell and its application as solid-state electrochemiluminescence sensor material. J Phys Chem B 111:10448–10452. doi: 10.1021/jp0734427 CrossRefGoogle Scholar
  40. Zhang Y, Zeng GM, Tang L, Huang DL, Jiang XY, Chen YN (2007b) A hydroquinone biosensor using modified core-shell magnetic nanoparticles supported on carbon paste electrode. Biosens Bioelectron 22:2121–2126CrossRefGoogle Scholar
  41. Zwiener C, Glauner T, Frimmel FH (2002) Method optimization for the determination of carbonyl compounds in disinfected water by DNPH derivatization and LC-ESI-MS-MS. Anal Bioanal Chem 372:615–621CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of IsfahanIsfahanIran

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