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Effects of rs591323 on serotonin transporter availability in healthy male subjects

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Abstract

Objectives

We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls.

Methods

The study population consisted of healthy controls with screening 123I-FP-CIT single-photon emission computed tomography. Specific binding of 123I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons.

Results

One hundred sixty healthy controls (male 106, female 54, 61.0 ± 11.5 years) were included in this study. Sex difference did not exist in DAT availabilities of caudate nucleus (p = 0.5344), putamen (p = 0.5006), and striatum (p = 0.5056). However, male subjects had higher SERT availabilities of both midbrain (p = 0.0436), and pons (p = 0.0061). Therefore, we analyzed the effect of SNP on DAT availabilities of subjects in all, and that on SERT availabilities of males and females separately. None of 19 SNPs included in this study showed the effect on DAT availabilities. However, rs591323 in Fibroblast Growth Factor 20 on chromosome 8 had a significant impact on SERT availability of both midbrain (p = 0.0056) and pons (p = 0.0007).

Conclusion

SNP rs591323 of risk loci for Parkinson’s disease is associated with SERT availability of healthy male subjects.

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Acknowledgements

PPMI—a public–private partnership—is funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including abbVie, Avid, Biogen, Bristol-Myers Squibb, COVANCE, GE Healthcare, Genentech, GlaxoSmithKline, Lundbeck, Lilly, Merck, MesoScaleDiscovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, TEVA, and UCB.

Funding

None.

Author information

Author notes

  1. Kyoungjune Pak, Hyun-Yeol Nam, Seong-Jang Kim and In Joo Kim contributed equally as corresponding authors in this work.

Authors and Affiliations

  1. Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea

    Kyoungjune Pak, Seunghyeon Shin, Keunyoung Kim & In Joo Kim

  2. Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea

    Hyun-Yeol Nam

  3. Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea

    Myung Jun Lee & Eun-Joo Kim

  4. Department of Neurosurgery and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea

    Jae Meen Lee

  5. Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea

    Seong-Jang Kim

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  1. Kyoungjune Pak
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Correspondence to Kyoungjune Pak, Hyun-Yeol Nam, Seong-Jang Kim or In Joo Kim.

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Pak, K., Nam, HY., Shin, S. et al. Effects of rs591323 on serotonin transporter availability in healthy male subjects. Ann Nucl Med 32, 431–436 (2018). https://doi.org/10.1007/s12149-018-1262-z

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  • DOI: https://doi.org/10.1007/s12149-018-1262-z

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