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FDG PET/CT allowing detection and follow-up of tumor cell transplantation

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Abstract

After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed abnormal increased uptake of the renal graft, associated with hypermetabolic lymph nodes and hepatic, pulmonary and bone lesions. Emergency graft resection was performed 5 days after PET/CT, permitting immunosuppressive therapy withdrawal. Pathologic examination of the kidney showed parenchymal infiltration by tumor cells compatible with small cell lung cancer. Thereafter, pathologists proved that the recipient’s and donor’s tumor cells matched using microsatellite markers. FDG-PET/CT was performed in the follow-up and showed progression in the donor despite chemotherapy and radiotherapy. He died a few months later. However, FDG-PET/CT showed a complete metabolic response after only 3 courses of chemotherapy in the recipient.

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Authors and Affiliations

  1. CHU of Lille, Department of Nuclear Medicine, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France

    Alice Jaillard, Clio Baillet, Amandine Béron & Damien Huglo

  2. CHU of Lille, Department of Nephrology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France

    Nahid Tabibzadeh, Marie Frimat & Christian Noël

  3. CHU of Lille, Department of Pulmonary and Thoracic Oncology, Hôpital Albert Calmette, 2 Avenue Oscar Lambret, 59000, Lille, France

    Arnaud Scherpereel

  4. Université de Lille, Faculté de Médecine, Place de Verdun, 59000, Lille, France

    Arnaud Scherpereel, Christian Noël & Damien Huglo

  5. CHU of Lille, Department of Anatomopathology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France

    Romain Perbet & Vivianne Gnemmi

Authors
  1. Alice Jaillard
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  2. Clio Baillet
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  3. Amandine Béron
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  4. Nahid Tabibzadeh
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  5. Arnaud Scherpereel
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  6. Marie Frimat
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  7. Romain Perbet
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  8. Vivianne Gnemmi
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  9. Christian Noël
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  10. Damien Huglo
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Corresponding author

Correspondence to Alice Jaillard.

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Jaillard, A., Baillet, C., Béron, A. et al. FDG PET/CT allowing detection and follow-up of tumor cell transplantation. Ann Nucl Med 30, 250–254 (2016). https://doi.org/10.1007/s12149-015-1051-x

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  • DOI: https://doi.org/10.1007/s12149-015-1051-x

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