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Two-Year Experience of the Implementation of the Milan for Reporting Salivary Gland Cytopathology at a Private Medical Laboratory

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Abstract

This study aimed to present the 2-year experience of the implementation of the Milan System for Reporting Salivary Gland Cytopathology at Alpha Prolipsis Medical Laboratories, a private medical laboratory located in Athens, Greece. A totaI of 102 Fine Needle Aspirations (FNAs) performed since 2018 were included in the study. Reports were issued according to the Milan System for Reporting Salivary Gland Cytopathology. Aspirates were prepared with both conventional and liquid-based cytological methods and were evaluated by two or three Board-certified cytopathologists. Diagnostic reproducibility and accuracy were evaluated. All cases included in this study had histologic follow-up. The diagnostic accuracy of FNA for differentiating between benign and malignant disease according to MSRSGC classification was 93.3%, the specificity was 97.5% and the sensitivity was 82.2%. The positive and negative predictive values were 93.2 and 87.2%, respectively. Our results show that FNA is a valuable examination technique in the preoperative evaluation of salivary gland lesions. The integration of the 2018 Milan System for Reporting Salivary Gland Cytopathology is effective, with an overall accuracy around 95%.

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References

  1. Seethala RR, Stenman G. Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of the salivary gland. Head Neck Pathol. 2017;11:55–67. https://doi.org/10.1007/s12105-017-0795-0.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Filopoulos E, Angeli S, Daskalopoulou D, Kelessis N. Vassilopoulos pre-operative evaluation of parotid tumours by fine needle biopsy. Eur J Surg Oncol. 1998;24(3):180–3. https://doi.org/10.1016/s0748-7983(98)92895-5.

    Article  CAS  PubMed  Google Scholar 

  3. Colella G, Cannavale R, Flamminio F, Foschini MP. Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg. 2010;68:2146–53. https://doi.org/10.1016/j.joms.2009.09.064.

    Article  PubMed  Google Scholar 

  4. Rossi ED, Faquin WC. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an international effort toward improved patient care-when the roots might be inspired by Leonardo da Vinci. Cancer Cytopathol. 2018;126(9):756–66. https://doi.org/10.1002/cncy.22040.

    Article  PubMed  Google Scholar 

  5. Pusztaszeri M, Rossi ED, Baloch ZW, Faquin WC. Salivary gland fine needle aspiration and introduction of the Milan Reporting System. Adv Anat Pathol. 2019;26(2):84–92. https://doi.org/10.1097/PAP.0000000000000224.

    Article  PubMed  Google Scholar 

  6. Layfield LJ, Esebua M, Yang Z, Vatzmitsel M, Giorgadze T, Schmidt R. The Milan system for reporting salivary gland cytopathology: a study of inter-observer reproducibility. Diagn Cytopathol. 2019;47(8):765–8. https://doi.org/10.1002/dc.24187.

    Article  PubMed  Google Scholar 

  7. Jain R, Gupta R, Kudesia M, Singh S. Fine needle aspiration cytology in diagnosis of salivary gland lesions: a study with histologic comparison. Cytojournal. 2013;10:5. https://doi.org/10.4103/1742-6413.109547.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kocjan G, Nayagam M, Harris M. Fine needle aspiration cytology of salivary gland lesions: advantages and pitfalls. Cytopathology. 1990;1:269–75. https://doi.org/10.1111/j.1365-2303.1990.tb00360.x.

    Article  CAS  PubMed  Google Scholar 

  9. Jayaram G, Verma AK, Sood N, Khurana N. Fine needle aspiration cytology of salivary gland lesions. J Oral Pathol Med. 1994;23:256–61. https://doi.org/10.1111/j.1600-0714.1994.tb00055.x.

    Article  CAS  PubMed  Google Scholar 

  10. Schindler S, Nayar R, Dutra J, Bedrossian CW. Diagnostic challenges in aspiration cytology of the salivary glands. Semin Diagn Pathol. 2001;18:124–46.

    CAS  PubMed  Google Scholar 

  11. Chakrabarti S, Bera M, Bhattacharya PK, et al. Study of salivary gland lesions with fine needle aspiration cytology and histopathology along with immunohistochemistry. J Indian Med Assoc. 2010;108:833–6.

    PubMed  Google Scholar 

  12. Postema RJ, van Velthuysen ML, van den Brekel MW, Balm AJ, Peterse JL. Accuracy of fine-needle aspiration cytology of salivary gland lesions in the Netherlands Cancer Institute. Head Neck. 2004;26:418–24. https://doi.org/10.1002/hed.10393.

    Article  PubMed  Google Scholar 

  13. American Society of Cytopathology. The Milan system for reporting salivary gland cytopathology. http://www.cytopathology.org/the-milan-system-for-reporting-salivary-gland-cytopathology/ (2016). Accessed 31 March 2016

  14. Pastore A, Borin M, Malagutti N, Di Laora A, Beccati D, Delazer AL, Bianchini C, Stomeo F, Ciorba A, Pelucchi S. Preoperative assessment of salivary gland neoplasms with fine needle aspiration cytology and echography: a retrospective analysis of 357 cases. Int J Immunopathol Pharmacol. 2013;26:965–71. https://doi.org/10.1177/039463201302600416.

    Article  CAS  PubMed  Google Scholar 

  15. Chan MK, McGuire LJ, King W, Li AK, Lee JC. Cytodiagnosis of 112 salivary gland lesions. Correlation with histologic and frozen section diagnosis. Acta Cytol. 1992;36:353–63.

    CAS  PubMed  Google Scholar 

  16. Salehi S, Maleki Z. Diagnostic challenges and problem cases in salivary gland cytology: a 20-year experience. Cancer Cytopathol. 2018;126(2):101–11. https://doi.org/10.1002/cncy.21949.

    Article  PubMed  Google Scholar 

  17. Stewart CJ, MacKenzie K, McGarry GW, Mowat A. Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol. 2000;22:139–46.

    Article  CAS  Google Scholar 

  18. Orell SR. Diagnostic difficulties in the interpretation of fine needle aspirates of salivary gland lesions: the problem revisited. Cytopathology. 1995;6:285–300. https://doi.org/10.1111/j.1365-2303.1995.tb00574.x.

    Article  CAS  PubMed  Google Scholar 

  19. Ali NS, Akhtar S, Junaid M, Awan S, Aftab K. Diagnostic accuracy of fine needle aspiration cytology in parotid lesions. ISRN Surg. 2011;2011:721525. https://doi.org/10.5402/2011/721525.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Ashraf A, Shaikh AS, Kamal F, Sarfraz R, Bukhari MH. Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol. 2010;38:499–504. https://doi.org/10.1002/dc.21211.

    Article  PubMed  Google Scholar 

  21. Archondakis S, Georgoulakis J, Stamataki M, Anninos D, Skagias L, Panayiotides I, Peros G, Karakitsos P. Telecytology: a tool for quality assessment and improvement in the evaluation of thyroid fine-needle aspiration specimens. Telemed J E Health. 2009;15:713–7. https://doi.org/10.1089/tmj.2009.0037.

    Article  PubMed  Google Scholar 

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All authors conceived of the presented idea. SA performed the computations and supervised the findings of this work. All authors discussed the results and contributed to the final manuscript.

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Correspondence to Stavros Archondakis.

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The authors have no conflict of interest to declare.

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The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments and was approved by ALPHA PROLIPSIS Cytology laboratories research ethics committee.

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Archondakis, S., Roma, M. & Kaladelfou, E. Two-Year Experience of the Implementation of the Milan for Reporting Salivary Gland Cytopathology at a Private Medical Laboratory. Head and Neck Pathol 15, 780–786 (2021). https://doi.org/10.1007/s12105-020-01278-1

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