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Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study

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An Author Correction to this article was published on 14 July 2021

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Abstract

Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results. We report a case of a 12-year-old female patient with a CGCG of the left maxilla that was treated with 40 doses of intralesional triamcinolone acetonide infiltrations combined with alendronate sodium and calcium carbonate. Clinical and imaging follow-up over 12 years demonstrates improvement in the patient’s condition.

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Authors and Affiliations

  1. Department of Oral Pathology, School of Dentistry, Federal University of Ceara, Rua Monsenhor Furtado, Fortaleza, Ceara, 60430-355, Brazil

    Raíssa Pinheiro de Mendonça

  2. Department of Oral Pathology, School of Dentistry, Federal University of Para, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil

    Geovanni Pereira Mitre, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior & João de Jesus Viana Pinheiro

  3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Federal University of Para, Avenida Augusto Correa, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil

    Flavio Henrique Real & Newton Guerreiro Da Silva Júnior

  4. Belem, Brazil

    Paulo Vianna

  5. Cell Culture Laboratory, Department of Oral Pathology, School of Dentistry, Federal University of Para - UFPA - Institute of Health Sciences, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil

    João de Jesus Viana Pinheiro

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  1. Raíssa Pinheiro de Mendonça
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  2. Geovanni Pereira Mitre
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  7. Newton Guerreiro Da Silva Júnior
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  8. João de Jesus Viana Pinheiro
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Correspondence to João de Jesus Viana Pinheiro.

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de Mendonça, R.P., Mitre, G.P., Real, F.H. et al. Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study. Head and Neck Pathol 14, 497–502 (2020). https://doi.org/10.1007/s12105-019-01053-x

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  • DOI: https://doi.org/10.1007/s12105-019-01053-x

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