Calcifying Odontogenic Cyst Showing a Varied Epithelial Lining: An Additional Case with Implications for the Divergent Differentiation Capacity of the Cyst Epithelium

  • Fumio Ide
  • Takashi Muramatsu
  • Yuji Miyazaki
  • Kentaro Kikuchi
  • Kaoru Kusama
Letter to the Editor

To the Editors,

Argyris and Koutlas [1] have described a single cystic lesion of orthokeratinized odontogenic cyst (OOC) and odontogenic keratocyst (OKC) with focal ghost cell keratinization/calcification in a patient with Gardner syndrome. They speculated that two distinct types of keratinizing OCs occurred simultaneously as separate foci within the same lesion under the common molecular (Wnt/β-catenin) pathway, since examination of multiple sections revealed that at no point were the two cysts in continuity. This is an interesting contribution demonstrating the morphological diversity that OCs may show [2, 3, 4]. Here we add an unusual case of calcifying odontogenic cyst (COC) in which the unicystic epithelium combined areas resembling dentigerous cyst (DC), OOC and OKC, with a minor component of mucous cells and duct-like structures. The COC lining also showed occasional granular parakeratosis (GP).

The patient, a 33-year-old man, presented with a painless facial swelling. The left...


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Conflict of interest

The authors declare no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Informed consent was obtained.


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Authors and Affiliations

  • Fumio Ide
    • 1
    • 2
  • Takashi Muramatsu
    • 3
  • Yuji Miyazaki
    • 1
  • Kentaro Kikuchi
    • 1
  • Kaoru Kusama
    • 1
  1. 1.Division of Oral Pathology, Department of Diagnostic and Therapeutic SciencesMeikai University School of DentistrySakadoJapan
  2. 2.Department of Diagnostic PathologyTsurumi University School of Dental MedicineYokohamaJapan
  3. 3.Department of Operative Dentistry, Cariology and Pulp BiologyTokyo Dental CollegeTokyoJapan

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