Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence

  • Akeesha A. Shah
  • Eric D. Lamarre
  • Justin A. Bishop
Case Report

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.

Keywords

Human papillomavirus Multiphenotypic sinonasal carcinoma Adenoid cystic carcinoma Sinonasal carcinoma Carcinoma with adenoid cystic-like features 

References

  1. 1.
    Bishop JA, Guo TW, Smith DF, et al. Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol. 2013;37:185–92.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Bishop JA, Ogawa T, Stelow EB, et al. Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013;37:836–44.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Andreasen S, Bishop JA, Hansen TV, et al. Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. Histopathology. 2017;70:880–8.CrossRefPubMedGoogle Scholar
  4. 4.
    Hwang SJ, Ok S, Lee HM, et al. Human papillomavirus-related carcinoma with adenoid cystic-like features of the inferior turbinate: a case report. Auris Nasus Larynx. 2015;42:53–5.CrossRefPubMedGoogle Scholar
  5. 5.
    Bishop JA, Andreasen S, Hang JF, et al. HPV-related multiphenotypic sinonasal carcinoma: an expanded series of 49 cases of the tumor formerly known as HPV-related carcinoma with adenoid cystic carcinoma-like features. Am J Surg Pathol. 2017;41:1690–701.CrossRefPubMedGoogle Scholar
  6. 6.
    El-Naggar AK, Chen JCK, Grandis JR, Takata T, Slootweg PJ, editors. World Health Organization classification of head and neck tumours. 4th ed. Lyon: IARC Press; 2017.Google Scholar
  7. 7.
    Bishop JA, Ma XJ, Wang H, et al. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012;36:1874–82.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Seethala RR, Hunt JL, Baloch ZW, et al. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31:1683–94.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Akeesha A. Shah
    • 1
  • Eric D. Lamarre
    • 2
  • Justin A. Bishop
    • 3
  1. 1.Department of Pathology, Cleveland Clinic FoundationRobert J. Tomsich Pathology and Laboratory Medicine InstituteClevelandUSA
  2. 2.Head and Neck InstituteCleveland Clinic FoundationClevelandUSA
  3. 3.Department of PathologyUniversity of Texas Southwestern Medical CenterDallasUSA

Personalised recommendations