Utility and Safety of Transjugular Liver Biopsy in Children


Transjugular liver biopsy (TJLB) is widely used in adults when percutaneous liver biopsy (PLB) is contraindicated. The authors evaluated the safety, efficacy and utility of TJLB in pediatric patients with contraindications to PLB. Twenty-three children and adolescents (13 male) underwent 24 (one patient had two separate biopsies) consecutive biopsies (TJLB) under general anaesthesia (18) or intravenous sedation (6). PLB was contraindicated because of elevated prothrombin time (PT)/international normalized ratio (INR) (˃ 15.5/1.5) in 19 (79.2%) and thrombocytopenia (< 60,000/dL) in 15 (62.5%) procedures. Derangement in both INR and platelet count were found in 12 (50%) cases. Significant ascites was present in 10 (41.7%) procedures. Technical success rate with adequate biopsy sample was 95.8% (23/24) with no major complications. A new diagnosis was established in 9 (37.5%) cases. Another 14 (58.34%) biopsies confirmed the initial diagnoses. Four cases also revealed additional information guiding overall management and prognosis. Thus, TJLB is a safe and useful procedure in children.

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PM and RM conceived the study. PM, RM and KSM wrote the manuscript. SS reviewed the manuscript and edited it. SS will act as guarantor for this paper.

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Correspondence to Rohan Malik.

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Cleared by the Institutional Ethics Committee, AIIMS, New Delhi.

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Maji, P., Malik, R., Madhusudhan, K.S. et al. Utility and Safety of Transjugular Liver Biopsy in Children. Indian J Pediatr (2021). https://doi.org/10.1007/s12098-020-03650-z

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  • Liver biopsy
  • Coagulopathy
  • Ascites
  • Transjugular liver biopsy
  • Children