Abstract
Objective
To study the clinico-etiological profile of epilepsy in children aged 1–24 mo attending a tertiary-care public hospital.
Methods
All infants aged 1–24 mo with epilepsy (as per International League Against Epilepsy, 2014) presenting between April 2016 and March 2017 were enrolled. Detailed history and examination were done in all children, and developmental assessment was done using Developmental Assessment Scale for Indian Infants (DASII). Electroencephalography and neuroimaging (CT/MRI) were done for all subjects.
Results
Sixty children (39 males) were consecutively enrolled after informed written consent. The mean (SD) age at seizure onset was 4.3 (4.14) mo. Perinatal asphyxia (45%) and malformations of cortical development (18.3%) were the commonest etiologies. Neurological examination was abnormal in 68.3%, and a neuroimaging abnormality was present in 76% of children. Fifteen patients (25%) had West syndrome, which was symptomatic in the majority (73.3%). Developmental delay (DQ < 70) was the commonest co-morbidity (81.7%); 28.3% had profound delay. Odds of having developmental delay were 13-times higher in those with an abnormal neurological examination [OR 13.5 (2.82–64.67), P = 0.001], and nearly 9-times higher with abnormal neuroimaging [OR 8.9 (2.11–37.9), P = 0.003].
Conclusions
Epilepsy in children <2 y is symptomatic in the majority, with sequelae of birth asphyxia as the commonest etiology. High prevalence of co-morbid developmental delay underscores the need for routine evaluation and early intervention in all high-risk infants.
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References
Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and seizures in Rochester, Minnesota: 1935–1984. Epilepsia. 1993;34:453–6.
Wilmshurst JM, Gaillard WD, Vinayan KP, et al. Summary of recommendations for the management of infantile seizures: task force report for the ILAE Commission of Pediatrics. Epilepsia. 2015;56:1185–97.
Eltze CM, Chong WK, Cox T, et al. A population-based study of newly diagnosed epilepsy in infants. Epilepsia. 2013;54:437–45.
Altunbaşak S, Incecik F, Hergüner O, Refik Burgut H. Prognosis of patients with seizures occurring in the first 2 years. J Child Neurol. 2007;22:307–13.
Battaglia D, Randò T, Deodato F, et al. Epileptic disorders with onset in the first year of life: neurological and cognitive outcome. Eur J Paediatr Neurol. 1999;3:95–103.
Matsumoto A, Watanabe K, Sugiura M, Negoro T, Takaesu E, Iwase K. Etiologic factors and long-term prognosis of convulsive disorders in the first year of life. Neuropediatrics. 1983;14:231–4.
Kharod P, Mishra D, Juneja M. Drug-resistant epilepsy in Indian children at a tertiary-care public hospital. Childs Nerv Syst. 2019 Feb 13. https://doi.org/10.1007/s00381-019-04084-5 [Epub ahead of print].
Udani V, Munot P, Ursekar M, Gupta S. Neonatal hypoglycemic brain-injury: a common cause of infantile onset remote symptomatic epilepsy. Indian Pediatr. 2009;46:127–32.
Singhi P, Ray M. Profile of west syndrome in north Indian children. Brain Dev. 2005;27:135–40.
Sehgal R, Gulati S, Sapra S, Tripathi M, Kabra M, Pandey RM. Neurodevelopmental and epilepsy outcome in children aged one to five years with infantile spasms – a north Indian cohort. Epilepsy Res. 2014;108:526–34.
Nikunj NK, Mishra D, Juneja M, Talukdar B. Etiology and short-term outcome of first seizure in hospitalized infants. Indian Pediatr. 2016;53:924–6.
Wilmshurst JM, Birbeck GL, Newton CR. Epilepsy is ubiquitous, but more devastating in the poorer regions of the world... or is it? Epilepsia. 2014;55:1322–5.
Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55:475–82.
Phatak P. Manual for Using Developmental Assessment Scales for Indian Infants (DASII): Based on Revised Baroda Norms. Pune: Anand Agencies; 1997. p. 1–7.
Dhinakaran R, Mishra D. ILAE classification of seizures and epilepsies, 2017: an update for the pediatrician. Indian Pediatr. 2019;56:60–2.
Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:522–30.
Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:512–21.
Partikian A, Mitchell WG. Neurodevelopmental and epilepsy outcomes in a north American cohort of patients with infantile spasms. J Child Neurol. 2010;25:423–8.
Berg AT, Loddenkemper T, Baca CB. Diagnostic delays in children with early onset epilepsy: impact, reasons, and opportunities to improve care. Epilepsia. 2014;55:123–32.
Rantala H, Ingalsuo H. Occurrence and outcome of epilepsy in children younger than 2 years. J Pediatr. 1999;135:761–4.
Ahmed S, Alam ST, Rahman MM, Akhter S. Clinical profile of early childhood epilepsy: a cross sectional study in a tertiary care hospital. Mymensingh Med J. 2016;25:96–101.
Handryastuti S, Mangunatmadja I. Risk factors influencing the outcomes in infants with epilepsy. Paediatr Indonesia. 2007;47:202–6.
Hsieh DT, Chang T, Tsuchida TN, et al. New-onset afebrile seizures in infants: role of neuroimaging. Neurology. 2010;74:150–6.
Gaillard WD, Chiron C, Cross JH, et al; ILAE Committee for Neuroimaging, Subcommittee for Pediatric. Guidelines for imaging infants and children with recent-onset epilepsy. Epilepsia. 2009;50:2147–53.
Cheverie JJ, Aicardi J. Convulsive disorders in the first year of life: neurological and mental outcome and mortality. Epilepsia. 1978;19:67–74.
Masri A, Badran E, Hamamy H, Assaf A, Al-Qudah AA. Etiologies, outcomes, and risk factors for epilepsy in infants: a case-control study. Clin Neurol Neurosurg. 2008;110:352–6.
Vanderlinden L, Lagae LG. Clinical predictors for outcome in infants with epilepsy. Pediatr Neurol. 2004;31:52–5.
Acknowledgements
The authors are thankful to Dr. Sapna Singh, Professor, Department of Radiodiagnosis, for her help in reporting on the study investigations.
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PKS, DM, MJ, KT: Study planning; PKS, DM: Subject assessment and evaluation; DM, KT: Statistical analysis; PKS, KT, DM: Manuscript writing. All authors made important intellectual contribution to study planning, data analysis, and manuscript writing. All authors approved the final manuscript. DM would be the guarantor.
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Sahu, P.K., Mishra, D., Juneja, M. et al. Clinico-etiological Profile and Developmental Status of Infants Aged 1–24 months with Epilepsy. Indian J Pediatr 86, 681–685 (2019). https://doi.org/10.1007/s12098-019-02943-2
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DOI: https://doi.org/10.1007/s12098-019-02943-2