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Pulmonary Hemorrhage in Children: Etiology, Clinical Profile and Outcome

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Abstract

Objective

To describe etiology, clinical profile, treatment and outcome of children with pulmonary hemorrhage.

Methods

A chart review of children with pulmonary hemorrhage attending Pediatric Pulmonology services of a tertiary care hospital in North-India was done.

Results

Data of 44 children (mean age 59.2 ± 32.1 mo; 28 boys) were included for the study. Possible idiopathic pulmonary hemosiderosis 16 (36.4%), post infectious complications 11 (25%), immune mediated disorders 8 (18.2%), cardiac and vascular disorders 7 (15.9%), and airway pathologies 2 (4.5%) were the etiologies of pulmonary hemorrhage. Treatment options like medications, bronchial artery embolization and surgical resections were offered according to the etiology. Children with idiopathic pulmonary hemosiderosis and those with immune mediated diseases were treated with systemic steroids and steroid sparing agents; the latter group took longer time to respond and had more relapses.

Conclusions

Identification of main etiological categories of pulmonary hemorrhage in children could be useful to plan investigations and management of wide range of causes in more practical way.

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References

  1. Lazor R. Alveolar haemorrhage syndromes. Eur Respir Mon. 2011;54:15–31.

    Google Scholar 

  2. Parris D, van Niekerk A, Jeevarathnum AC, Green RJ. An approach to pulmonary haemorrhage in children. S Afr Respir J. 2017;23:63–70.

    Google Scholar 

  3. Susarla SC, Fan LL. Diffuse alveolar hemorrhage syndromes in children. Curr Opin Pediatr. 2007;19:314–20.

    Article  PubMed  Google Scholar 

  4. Krause ML, Cartin-Ceba R, Specks U, Peikert T. Update on diffuse alveolar hemorrhage and pulmonary vasculitis. Immunol Allergy Clin N Am. 2012;32:587–600.

    Article  Google Scholar 

  5. de Prost N, Parrot A, Cuquemelle E, et al. Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited. Respir Med. 2012;106:1021–32.

    Article  PubMed  Google Scholar 

  6. Lara AR, Schwarz MI. Diffuse alveolar hemorrhage. Chest. 2010;137:1164–71.

    Article  PubMed  Google Scholar 

  7. Kabra SK, Bhargava S, Lodha R, Satyavani A, Walia M. Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children. Indian Pediatr. 2007;44:333–8.

    PubMed  CAS  Google Scholar 

  8. Taytard J, Nathan N, de Blic J, et al; French RespiRare® group. New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare® cohort. Orphanet J Rare Dis. 2013;8:161.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Zhang X, Wang L, Lu A, Zhang M. Clinical study of 28 cases of paediatric idiopathic pulmonary haemosiderosis. J Trop Pediatr. 2010;56:386–90.

    Article  PubMed  Google Scholar 

  10. Quadrelli S, Dubinsky D, Solis M, et al. Immune diffuse alveolar hemorrhage: clinical presentation and outcome. Respir Med. 2017;129:59–62.

    Article  PubMed  Google Scholar 

  11. Castellazzi L, Patria MF, Frati G, Esposito AA, Esposito S. Idiopathic pulmonary haemosiderosis in paediatric patients: how to make an early diagnosis. Ital J Pediatr. 2016;42:86.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Singh D, Bhalla AS, Veedu PT, Arora A. Imaging evaluation of hemoptysis in children. Ital J Pediatr. 2013;2:54–64.

    Google Scholar 

  13. Chin CIC, Kohn SL, Keens TG, Margetis MF, Kato RM. A physician survey reveals differences in management of idiopathic pulmonary hemosiderosis. Orphanet J Rare Dis. 2015;10:98.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sethi GR, Singhal KK, Puri AS, Mantan M. Benefit of gluten-free diet in idiopathic pulmonary hemosiderosis in association with celiac disease. Pediatr Pulmonol. 2011;46:302–5.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India

    Channa de Silva, Aparna Mukherjee, Kana Ram Jat, Rakesh Lodha & Sushil Kumar Kabra

Authors
  1. Channa de Silva
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  2. Aparna Mukherjee
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  3. Kana Ram Jat
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  4. Rakesh Lodha
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  5. Sushil Kumar Kabra
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Contributions

CDS: Data collection, interpretation and manuscript writing; AM, KRJ, RL and SKK: Data interpretation and critically evaluated the manuscript; SKK: Conceptualized the study and will act as the guarantor for the paper. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Sushil Kumar Kabra.

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de Silva, C., Mukherjee, A., Jat, K.R. et al. Pulmonary Hemorrhage in Children: Etiology, Clinical Profile and Outcome. Indian J Pediatr 86, 7–11 (2019). https://doi.org/10.1007/s12098-018-2725-x

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  • DOI: https://doi.org/10.1007/s12098-018-2725-x

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