The Role of Presepsin Obtained from Tracheal Aspirates in the Diagnosis of Early Onset Pneumonia in Intubated Newborns
To investigate the role of presepsin obtained from tracheal aspirate of intubated newborns in the diagnosis of early neonatal pneumonia.
A cross-sectional observational study was performed on 60 intubated newborns during the two-year period. Tracheal aspirate for examination was taken in aseptic conditions in usual toilets, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. On the same day, presepsin (blood) was measured.
There were 34 newborns in the examined group (with pneumonia) and 26 in the control group. Patient groups were similar regarding demographic characteristics related to gender and Apgar score. The coefficients of simple linear correlation revealed the statistically significant connection between presepsin (from tracheal aspirate) and birth body weight, presepsin (plasma), maternal infection and pneumonia. Significant differences in the values of presepsin (from tracheal aspirate) (p < 0.001) and birth body weight (p = 0.036) were found.
In intubated newborns, measurements of presepsin obtained from tracheal aspirate suggested that it can be used as a complementary marker in diagnosing early onset neonatal pneumonia.
KeywordsPresepsin Tracheal aspirate Early neonatal pneumona Intubated newborns
DS: Idea, writing the manuscript; AS and ZI: Writing the manuscript; SM: Analysis and interpretation of the data; GK: Acquiring and collecting the data; BV: The form of the study and the method of carrying out the study; SR and ML: Participation in biochemical analyzes; RP: Critical correction (revision) of the manuscript. ZI will act as guarantor for this paper.
Compliance with Ethical Standards
Conflict of Interest
- 5.Ishikura H, Nishida T, Murai A, et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study. Crit Care. 2014;18:R19.Google Scholar
- 6.Spanuth E, Ebelt H, Ivandic B, et al. Diagnostic and prognostic value of presepsin (soluble CD14 subtype) in emergency patients with early sepsis using the new assay PATHFAST Presepsin. 21st International Congress of Clinical Chemistry and Laboratory Medicine. Berlin: IFCC-WorldLab – EuroMedLab, 15–19 May 2011. Poster 0333.Google Scholar
- 7.Marcos V, Latzin P, Hector A, et al. Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases. Respir Res. 2010;11:32.Google Scholar
- 12.Stoll BJ, Hansen N, Fanaroff AA, et al. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Engl J Med. 2002;347:240–7.Google Scholar
- 14.Wortham JM, Hansen NI, Schrag SJ, et al; Eunice Kennedy Shriver NICHD Neonatal Reserach Network. Chorioamnionitis and culture-confirmed, early-onset neonatal infections. Pediatrics. 2016;137:e20152323. https://doi.org/10.1542/peds.2015-2323.
- 17.Shozushima T, Takahashi G, Matsumoto N, Kojika M, Okamura Y, Endo S. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother. 2011;17:764–9.CrossRefPubMedGoogle Scholar
- 18.Endo S, Suzuki Y, Takahashi G, et al. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother. 2012;18:891–7.Google Scholar