Prediction of Neonatal Hyperbilirubinemia Using 1st Day Serum Bilirubin Levels

  • S. M. Spoorthi
  • Siddappa F. Dandinavar
  • Vinod H. Ratageri
  • Prakash K. Wari
Clinical Brief
  • 16 Downloads

Abstract

The study was conducted on Full term neonates with birth weight > 2.5 kg born in KIMS, Hubballi with an objective to determine the first day Total Serum Bilirubin (TSB) value so as to predict subsequent development of significant hyperbilirubinemia in term neonates. All enrolled neonates were sampled for TSB and blood group on Day 1 at 20 ± 4 h and then followed up clinically by Kramer’s rule and when the clinical jaundice by Kramer’s rule was >10 mg/dl, TSB levels were repeated. A total of 180 newborns were enrolled for the study and 165 babies completed the study. Out of these, 17(10.3%) babies had significant hyperbilirubinemia by day 5 of life. Using Receiver Operating Characteristic (ROC) Curve, a cut off TSB value of 6.15 mg/dl was determined with sensitivity of 82.4%, specificity of 81.8%, positive predictive value of 32.8%, negative predictive value 97.6%. In term neonates, the first day total bilirubin level at 20 ± 4 h of life <6.15 predicts the low risk of subsequent significant hyperbilirubinemia with high probability.

Keywords

Hyperbilirubinemia Term neonates Bilirubin Prediction 

Notes

Contributions

SMS: Collected and analysed the data and wrote the manuscript; SFD: Constructed the plan of study, helped in writing the manuscript and supervised the work; VHR: Helped in data analysis, writing the manuscript and supervised the work; PKW: Helped and guided in writing the manuscript and supervised the work. VHR will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of PediatricsKarnataka Institute of Medical SciencesHubballiIndia
  2. 2.Department of Pediatrics, JJMMCDavanagereIndia

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