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Tools in Asthma Evaluation and Management: When and How to Use Them?

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Abstract

The goals of asthma management are accurate diagnosis, prompt initiation of treatment and monitoring of disease progression to limit potential morbidity and mortality. While the diagnosis and management is largely based on history taking and clinical examination, there are an increasing number of tools available that could be used to aid diagnosis, define phenotypes, monitor progress and assess response to treatment. Tools such as the Asthma Predictive Index could help in making predictions about the possibility of asthma in childhood based on certain clinical parameters in pre-schoolers. Lung function measurements such as peak expiratory flow, spirometry, bronchodilator responsiveness, and bronchial provocation tests help establish airway obstruction and variability over time. Tools such as asthma questionnaires, lung function measurements and markers of airway inflammation could be used in combination with clinical assessments to assess ongoing asthma control. Recent advances in digital technology, which open up new frontiers in asthma management, need to be evaluated and embraced if proven to be of value. This review summarises the role of currently available tools in asthma diagnosis and management. While many of the tools are readily available in resource rich settings, it becomes more challenging when working in resource poor settings. A rational approach to the use of these tools is recommended.

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References

  1. Morgan WJ, Stern DA, Sherrill DL, et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med. 2005;172:1253–8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tai A, Tran H, Roberts M, et al. Outcomes of childhood asthma to the age of 50 years. J Allergy Clin Immunol. 2014;133:1572–8.e3.

    Article  PubMed  Google Scholar 

  3. Torjesen I. Two thirds of deaths from asthma are preventable, confidential inquiry finds. BMJ. 2014;348:g3108.

    Article  PubMed  CAS  Google Scholar 

  4. Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol. 2007;42:723–8.

    Article  PubMed  Google Scholar 

  5. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000;162:1403–6.

    Article  PubMed  CAS  Google Scholar 

  6. Global Initiative for Asthma. Global Strategies for Asthma Management and Prevention, 2017. Available at: www.ginasthma.org. Accessed on 10th April 2017.

  7. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26:948–68.

    Article  PubMed  CAS  Google Scholar 

  8. Beydon N, Davis SD, Lombardi E, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med. 2007;175:1304–5.

    Article  PubMed  Google Scholar 

  9. Quanjer PH, Stanojevic S, Cole TJ, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40:1324–43.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Raywood E, Lum S, Aurora P, Pike K. The bronchodilator response in preschool children: a systematic review. Pediatr Pulmonol. 2016;51:1242–50.

    Article  PubMed  Google Scholar 

  11. James DR, Lyttle MD. British guideline on the management of asthma: SIGN clinical guideline 141, 2014. Arch Dis Child Educ Pract Ed. 2016;101:319–22.

    Article  PubMed  Google Scholar 

  12. Borrego LM, Stocks J, Almeida I, et al. Bronchodilator responsiveness using spirometry in healthy and asthmatic preschool children. Arch Dis Child. 2013;98:112–7.

    Article  PubMed  Google Scholar 

  13. Busi LE, Restuccia S, Tourres R, Sly PD. Assessing bronchodilator response in preschool children using spirometry. Thorax. 2017;72:367–72.

    Article  PubMed  Google Scholar 

  14. Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD. Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care Med. 2004;169:850–4.

    Article  PubMed  Google Scholar 

  15. Carlsen KH, Engh G, Mork M, Schroder E. Cold air inhalation and exercise-induced bronchoconstriction in relationship to metacholine bronchial responsiveness: different patterns in asthmatic children and children with other chronic lung diseases. Respir Med. 1998;92:308–15.

    Article  PubMed  CAS  Google Scholar 

  16. Riedler J, Reade T, Dalton M, Holst D, Robertson C. Hypertonic saline challenge in an epidemiologic survey of asthma in children. Am J Respir Crit Care Med. 1994;150:1632–9.

    Article  PubMed  CAS  Google Scholar 

  17. Verini M, Peroni DG, Rossi N, et al. Functional assessment of allergic asthmatic children while asymptomatic. Allergy Asthma Proc. 2006;27:359–64.

    Article  PubMed  Google Scholar 

  18. Mahut B, Trinquart L, Bokov P, et al. Relationships between specific airway resistance and forced expiratory flows in asthmatic children. PLoS One. 2009;4:e5270.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Kooi EM, Schokker S, van der Molen T, Duiverman EJ. Airway resistance measurements in pre-school children with asthmatic symptoms: the interrupter technique. Respir Med. 2006;100:955–64.

    Article  PubMed  CAS  Google Scholar 

  20. Shi Y, Aledia AS, Galant SP, George SC. Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children. J Allergy Clin Immunol. 2013;131:718–23.

    Article  PubMed  Google Scholar 

  21. Skylogianni E, Douros K, Anthracopoulos MB, Fouzas S. The forced oscillation technique in paediatric respiratory practice. Paediatr Respir Rev. 2016;18:46–51.

    PubMed  Google Scholar 

  22. van der Heijden HH, Brouwer ML, Hoekstra F, van der Pol P, Merkus PJ. Reference values of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing. Pediatr Pulmonol. 2014;49:291–5.

    Article  PubMed  Google Scholar 

  23. National Institute for Health and Care Excellence (NICE). Asthma: diagnosis and monitoring of asthma in adults, children and young people (draft for consultation). London: NICE; 2015.

    Google Scholar 

  24. Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–15.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Sachs-Olsen C, Lodrup Carlsen KC, Mowinckel P, et al. Diagnostic value of exhaled nitric oxide in childhood asthma and allergy. Pediatr Allergy Immunol. 2010;21:e213–21.

    Article  PubMed  CAS  Google Scholar 

  26. Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy. 2013;68:531–8.

    Article  PubMed  CAS  Google Scholar 

  27. Carroll WD, Lenney W, Child F, et al. Asthma severity and atopy: how clear is the relationship? Arch Dis Child. 2006;91:405–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  28. Sly PD, Boner AL, Bjorksten B, et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet. 2008;372:1100–6.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Juniper EF, Gruffydd-Jones K, Ward S, Svensson K. Asthma control questionnaire in children: validation, measurement properties, interpretation. Eur Respir J. 2010;36:1410–6.

    Article  PubMed  CAS  Google Scholar 

  30. Jia CE, Zhang HP, Lv Y, et al. The asthma control test and asthma control questionnaire for assessing asthma control: systematic review and meta-analysis. J Allergy Clin Immunol. 2013;131:695–703.

    Article  PubMed  Google Scholar 

  31. Voorend-van Bergen S, Vaessen-Verberne AA, de Jongste JC, Pijnenburg MW. Asthma control questionnaires in the management of asthma in children: a review. Pediatr Pulmonol. 2015;50:202–8.

    Article  PubMed  CAS  Google Scholar 

  32. Pijnenburg MW, Baraldi E, Brand PL, et al. Monitoring asthma in children. Eur Respir J. 2015;45:906–25.

    Article  PubMed  Google Scholar 

  33. Baker RR, Mishoe SC, Zaitoun FH, Arant CB, Lucas J, Rupp NT. Poor perception of airway obstruction in children with asthma. J Asthma. 2000;37:613–24.

    Article  PubMed  CAS  Google Scholar 

  34. Fuhlbrigge AL, Kitch BT, Paltiel AD, et al. FEV(1) is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol. 2001;107:61–7.

    Article  PubMed  CAS  Google Scholar 

  35. Nuijsink M, Hop WC, Sterk PJ, Duiverman EJ, de Jongste JC. Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. Eur Respir J. 2007;30:457–66.

    Article  PubMed  CAS  Google Scholar 

  36. Kamps AW, Roorda RJ, Brand PL. Peak flow diaries in childhood asthma are unreliable. Thorax. 2001;56:180–2.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Reddel HK, Marks GB, Jenkins CR. When can personal best peak flow be determined for asthma action plans? Thorax. 2004;59:922–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Meena RK, Raj D, Lodha R, Kabra SK. Fractional exhaled nitric oxide for identification of uncontrolled asthma in children. Indian Pediatr. 2016;53:307–10.

    Article  PubMed  Google Scholar 

  39. Petsky HL, Kew KM, Chang AB. Exhaled nitric oxide levels to guide treatment for children with asthma. Cochrane Database Syst Rev. 2016;11:CD011439.

    PubMed  Google Scholar 

  40. Gibson PG, Grootendor DC, Henry RL, et al. Sputum induction in children. Eur Respir J Suppl. 2002;37:44s–6s.

  41. Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med. 2005;171:1077–82.

    Article  PubMed  Google Scholar 

  42. Fleming L, Wilson N, Regamey N, Bush A. Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax. 2012;67:193–8.

    Article  PubMed  Google Scholar 

  43. Lex C, Jenkins G, Wilson NM, et al. Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma? Pediatr Pulmonol. 2007;42:298–303.

    Article  PubMed  Google Scholar 

  44. Thomas PS, Lowe AJ, Samarasinghe P, et al. Exhaled breath condensate in pediatric asthma: promising new advance or pouring cold water on a lot of hot air? A systematic review. Pediatr Pulmonol. 2013;48:419–42.

    Article  PubMed  CAS  Google Scholar 

  45. Morton RW, Elphick HE, Rigby AS, et al. STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma. Thorax. 2017;72:347–54.

    Article  PubMed  Google Scholar 

  46. Huckvale K, Car M, Morrison C, Car J. Apps for asthma self-management: a systematic assessment of content and tools. BMC Med. 2012;10:144.

    Article  PubMed  PubMed Central  Google Scholar 

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Contributions

AM and AA: Did a review of literature, wrote part of the manuscript and reviewed the manuscript; NP: Conceptualised the manuscript, wrote part of the manuscript, reviewed, approved the final draft of the manuscript and will act as guarantor for the paper. Anna Mulholland is a clinical and research fellow funded by The Starship Foundation.

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Correspondence to Naveen Pillarisetti.

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Mulholland, A., Ainsworth, A. & Pillarisetti, N. Tools in Asthma Evaluation and Management: When and How to Use Them?. Indian J Pediatr 85, 651–657 (2018). https://doi.org/10.1007/s12098-017-2462-6

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  • DOI: https://doi.org/10.1007/s12098-017-2462-6

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