Overall survival for early and locally advanced non-small-cell lung cancer from one institution: 2000–2017



Lung cancer is the leading cause of cancer death in Spain. The objective of our study was to evaluate the characteristics of patients diagnosed with stages I–III non-small-cell lung cancer, as well as the impact that epidemiological changes, diagnostic improvements and surgical therapeutic innovations have had on survival in the past 20 years.


Retrospective analysis of patients diagnosed with early and locally advanced non-small-cell lung cancer between years 2000 and 2017 in our institution.


A total of 859 patients were included. An increase in the percentage of women diagnosed over time was observed. Statistically significant differences were observed in the mean age at diagnosis, with a progressive increase in the different periods. The percentage of current or former smokers was similar in all periods. Adenocarcinoma was the most frequent histologic type with a progressive increase in its frequency. The percentage of patients diagnosed in early stages has been increasing over the years. In stages I–II, there was a significant increase in the median survival (29.7 months: 2000–2004, 68.73 months: 2010–2014) that could be seen in stage III as well (14.7 months: 2000–2004, 30.63 months: 2015–2017).


A variation of clinical characteristics of lung cancer in Spain has been observed in recent years, as well as an improvement in survival in early and locally advanced stages, due not only to the treatments, but also to a more accurate detection of these tumors. Little progress has been made in tobacco habit with high stable percentages over the years.

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This paper is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 875160.

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All authors made substantial contributions to the conception or design of the work and the acquisition, analysis and interpretation of data; drafted the work and revised it critically for important intellectual content; approved the version to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding authors

Correspondence to V. Calvo or M. Provencio.

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Conflict of interest

Dr. M. Provencio has received personal fees from Bristol-Myers Squibb, Merck Sharp & Dohme (MSD), Roche, AstraZeneca and Takeda. Dr. V. Calvo has received personal fees from Bristol-Myers Squibb (BMS), Merck Sharp & Dohme (MSD), Roche, AstraZeneca and Takeda. The other authors do not have conflicts of interest to declare.

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Ethical approval was waived by the local Ethics Committee of Hospital Universitario Puerta de Hierro in view of the retrospective nature of the study.

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González, M., Calvo, V., Redondo, I. et al. Overall survival for early and locally advanced non-small-cell lung cancer from one institution: 2000–2017. Clin Transl Oncol (2021). https://doi.org/10.1007/s12094-020-02521-5

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  • Early-stage
  • Locally advanced stage
  • Non-small-cell lung cancer
  • Survival