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Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis

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Abstract

Introduction

Hypofractionated whole breast irradiation (HWBI) is the current standard of treatment after breast conservative surgery (BCS). Intraoperative radiotherapy (IORT) must be associated to WBI in patients showing high-risk factors of local recurrence in the definitive pathology report. The aim of this trial was to evaluate, for the first time, the acute toxicity and cosmesis of HWBI after photon-IORT.

Materials and methods

Twenty-six luminal breast cancer patients treated by BCS and IORT(20 Gy) were included between February and December 2019, in this prospective trial, of adjuvant HWBI (40.5 Gy/2.67 Gy/15 fractions). Acute toxicity (CTCAEv5.0) and cosmesis (Harvard scale), were assessed 3 months after treatment.

Results

All patients completed their treatment without interruptions. All cases were evaluable 3 months after treatment showing no toxicity ≥ G3 and excellent/good cosmesis assessment in 88% of the patients.

Conclusion

HWBI seems to have similar acute toxicity and cosmesis results than conventionally fractionated WBI in combination to photon-IORT after BCS.

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Funding

Breast Cancer Grant 2019-0001 Hospital Universitario San Roque/Universidad Fernando Pessoa Canarias.

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Authors and Affiliations

  1. Breast Cancer Unit, Centro Oncológico Integral Canario (COIC), Hospital Universitario San Roque, Dolores de la Rocha 5, 35001, Las Palmas, GC, Spain

    J. Burgos-Burgos, V. Vega, D. Macias-Verde, V. Gómez, M. Travieso-Aja, J. Travieso, E. Vicente, C. Santana, J. Ospina & P. C. Lara

  2. Universidad Fernando Pessoa Canarias. Dolores de La Rocha 14, 35001, Las Palmas, GC, Spain

    V. Gómez, J. Ospina & P. C. Lara

Authors
  1. J. Burgos-Burgos
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  2. V. Vega
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  3. D. Macias-Verde
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  4. V. Gómez
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  5. M. Travieso-Aja
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  6. J. Travieso
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  7. E. Vicente
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  8. C. Santana
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  9. J. Ospina
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  10. P. C. Lara
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Corresponding author

Correspondence to P. C. Lara.

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The authors declare that they have no conflict of interest.

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All human studies have been approved by the appropriate committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Burgos-Burgos, J., Vega, V., Macias-Verde, D. et al. Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis. Clin Transl Oncol 23, 179–182 (2021). https://doi.org/10.1007/s12094-020-02400-z

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  • DOI: https://doi.org/10.1007/s12094-020-02400-z

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