Positioning error analysis of the fraxion localization system in the intracranial stereotactic radiotherapy of tumors

Abstract

Objective

To investigate positioning error analysis of the Fraxion localization system in the intracranial stereotactic radiotherapy of tumors.

Methods

64 patients were divided into two groups: a control group (36 patients with the standard thermoplastic mask) and a model group (28 patients with the Fraxion localization system). 3D images of the treated position were obtained by cone-beam computed tomography (CBCT). Positioning errors were obtained by, respectively, registering these two sets of CBCT images to planning CT images, using a 6°-freedom robotic patient positioning system (HexaPOD Evo RT System). The changes in positioning errors with the Fraxion localization system and with the standard thermoplastic mask were analyzed.

Results

CBCT scan results of the model group showed that the mean of linear error of three directions [superior-inferior (SI), lateral (LAT), and anterior–posterior (AP)] was 0.710 ± 0.676 mm, 0.817 ± 0.687 mm, and 0.710 ± 0.685 mm, respectively. The corresponding PTV was 1.23 mm, 1.26 mm, and 1.36 mm. The differences between the 3D images and the planned CT images were significant (p < 0.001).

Conclusion

The Fraxion radiotherapy system can not only improve the positioning accuracy and reduce positioning errors but also narrow the PTV margin and reduce the radiated volume of normal tissue.

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Acknowledgements

We wish to thank all the members in our department for their discussion on this project. Revision E. Fraxion™ User Manual. Medical Intelligence Medizintechnik GmbH. Schwabmünchen. Germany 2013.

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Correspondence to J.-H. Han.

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The current study has been approved by the Ethical Committee of our hospital.

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He, DC., Zhu, ZJ., Zhang, XY. et al. Positioning error analysis of the fraxion localization system in the intracranial stereotactic radiotherapy of tumors. Clin Transl Oncol 23, 43–47 (2021). https://doi.org/10.1007/s12094-020-02382-y

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Keywords

  • Fraxion
  • Intracranial tumors
  • Stereotactic radiotherapy
  • Positioning errors
  • Localization system