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Lung cancer patients with a previous extra-pulmonary malignancy should not be considered homogeneous: a clinicopathological analysis of 3530 surgical cases

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Abstract

Background

Lung cancer patients with a previous extra-pulmonary malignancy have been widely discussed for their postoperative prognosis. Still, whether different types of previous extra-pulmonary malignancy confer different clinicopathological features and outcomes of lung cancer patients deserves further investigation.

Methods

The medical records of patients undergoing operation for pulmonary malignancy were retrospectively reviewed. After identifying primary lung cancer out of pulmonary metastasis in patients with a history of previous extra-pulmonary malignancy, clinicopathological parameters and postoperative prognosis were compared between lung cancer patients without and with different types of previous extra-pulmonary malignancy.

Results

Approximately, 5.0% lung cancer patients undergoing surgery had a previous extra-pulmonary malignancy. Prior breast cancer (20%) and colorectal cancer (16%) formed the majority of these previous extra-pulmonary malignancies. Many clinicopathological features such as reason for visit, tumor size and histological subtype were significantly different between lung cancer patients without and with different types of previous extra-pulmonary malignancy (P < 0.05). Lung cancer patients with a previous occurrence of breast cancer were the most different type from patients without a previous extra-pulmonary malignancy in clinicopathological features (P < 0.05). The postoperative overall survival was not significantly different between lung cancer patients without and with different types of previous extra-pulmonary malignancy (P > 0.05).

Conclusion

Previous extra-pulmonary malignancy was confirmed to be harmless to postoperative prognosis of lung cancer patients. Lung cancer patients with a previous extra-pulmonary malignancy, especially with a previous occurrence of breast cancer, were highly heterogeneous in clinicopathological features. These findings implied there might be a unique etiology existing in lung cancer following a previous occurrence of breast cancer.

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Funding

This work was supported by State’s Key Project of Research and Development Plan (2017YFC1310602, 2017YFC1310600), Shanghai Municipal Commission of Health and Family Planning (201540078).

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Author notes

  1. X.-L. Hu, S.-T. Xu and X.-C. Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    X.-L. Hu, X.-C. Wang, D.-N. Hou, C. Bao, D. Yang & Y.-L. Song

  2. Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

    S.-T. Xu

Authors
  1. X.-L. Hu
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  2. S.-T. Xu
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  3. X.-C. Wang
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  4. D.-N. Hou
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  5. C. Bao
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  6. D. Yang
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  7. Y.-L. Song
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Correspondence to D. Yang.

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All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Hu, XL., Xu, ST., Wang, XC. et al. Lung cancer patients with a previous extra-pulmonary malignancy should not be considered homogeneous: a clinicopathological analysis of 3530 surgical cases. Clin Transl Oncol 21, 348–354 (2019). https://doi.org/10.1007/s12094-018-1933-1

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  • DOI: https://doi.org/10.1007/s12094-018-1933-1

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