Factors associated with anxiety and depression in cancer patients prior to initiating adjuvant therapy
Anxiety and depression affect cancer patients’ quality of life. Our objectives were to determine the prevalence of anxiety and depression and analyze the association between positive psychological factors, sociodemographic factors, and clinical factors in oncological patients initiating adjuvant treatment.
A prospective, multicenter cohort of 600 consecutive patients completed the Brief Symptom Inventory, Mini-Mental Adjustment to Cancer, Life Orientation Scale-Revised, and Multidimensional Scale of Perceived Social Support questionnaires.
Prevalence of anxiety and depression was 49.8 and 36.6%, respectively. Women and younger individuals were more anxious and depressed than men and seniors. Employed participants suffered more anxiety than retirees, and singles exhibited more depression than married or partnered subjects. Logistic regression analysis showed that hope, optimism, social support, being male, and older were significantly associated with a lower risk of anxiety and depression (p < 0.001).
The high prevalence of anxiety and depression among Spaniards with cancer starting adjuvant chemotherapy suggests that more attention should be paid to mental health in these individuals. These findings are important for cancer patients because they can benefit from interventions that increase positive psychological factors such as hope, optimism, and social support to reduce anxiety and depression.
KeywordsAnxiety Cancer Depression Hope Optimism Social support
The study was supported by the FSEOM-Onvida for Projects on Long Survivors and Quality of Life. SEOM (Spanish Society of Medical Oncology) 2015.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest. This is an academic study.
The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its subsequent amendments. This study is an observational trial without intervention.
Signed informed consent was obtained from all patients.
- 4.Lee MS, Tyson DM, Gonzalez BD, Small BJ, Lechner SC, Antoni MH, et al. Anxiety and depression in Spanish-speaking Latina cancer patients prior to starting chemotherapy. Psychooncology. 2017;1–6.Google Scholar
- 9.Bao Y, Li L, Guan Y, Wang W, Liu Y, Wang P, et al. Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross-sectional study. 2017;269:262–9.Google Scholar
- 14.Derogatis LR. BSI 18, Brief Symptom Inventory 18: administration, scoring and procedures manual. NCS Pearson, Incorporated; 2001.Google Scholar
- 15.Merport A, Recklitis CJ. Does the Brief Symptom Inventory-18 case rule apply in adult survivors of childhood cancer?: comparison with the symptom checklist-90. 2012;37(6):650–9.Google Scholar
- 24.Lee MS, Martinez D, Gonzales BD, Small BJ, Lechner SC, Antoni MH, et al. Anxiety and depression in Spanish‐Speaking Latina cancer patients prior to starting chemotherapy. Psycho‐Oncology. 2017 (Epub ahead of print).Google Scholar
- 26.Class ML, Duarte JG, Graves K, Giwa KA. A contextual approach to understanding breast cancer survivorship among Latinas. 2012;124:115–24.Google Scholar
- 31.Harris J, Cornelius V, Ream E, Cheevers K, Armes J. Anxiety after completion of treatment for early-stage breast cancer: a systematic review to identify candidate predictors and evaluate multivariable model development. Support Care Cancer. 2017;25(7):2321–33.CrossRefPubMedPubMedCentralGoogle Scholar