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Clinical and Translational Oncology

, Volume 20, Issue 5, pp 570–575 | Cite as

Ki67 targeted strategies for cancer therapy

  • C. Yang
  • J. Zhang
  • M. Ding
  • K. Xu
  • L. Li
  • L. Mao
  • J. Zheng
Review Article
  • 240 Downloads

Abstract

Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review, we summarize recent advances in Ki67 targeted cancer therapy. In particular, we highlight recent development on the exploitation of Ki67 promoter to drive the expression of siRNAs or therapeutic genes in cancer cells specifically. The use of Ki67 as an attractive target opens a new avenue for cancer therapy.

Keywords

Ki67 Gene therapy Renal cancer siRNA Target therapy Proliferation 

Notes

Compliance with ethical standards

Funding

This study was funded by grants from Jiangsu Province Science Foundation (No. BK2007032), Project of Invigorating Health Care through Science, Technology and Education, and Jiangsu Provincial Medical Youth Talent.

Conflict of interest

All authors declare no conflict of interest.

Research involving human participants and/or animals

Not applicable.

Informed consent

Not applicable.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2017

Authors and Affiliations

  1. 1.Jiangsu Key Laboratory of Biological Cancer TherapyXuzhou Medical UniversityXuzhouChina
  2. 2.Department of Urinary SurgeryThe Affiliated Hospital of University Medical CollegeXuzhouChina

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