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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei and appendix tumours in elderly patients: Is it justified?

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Abstract

Background

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei and appendix tumours are widespread in the world. It is unclear what should be the attitude in elderly patients.

Methods

This retrospective multicenter study collected the database from ten Spanish centers from Spanish Group of Peritoneal Cancer Surgery. The study period was between November 2002 and March 2014. Seventeen patients with age greater than or equal to 75 years with peritoneal carcinomatosis from pseudomyxoma peritonei and appendix tumours met the selection criteria for the study. Outcomes in terms of morbidity and mortality such as disease-free and overall survival were analyzed.

Results

Median PCI was 16 (range 6–39). Ten postoperative adverse events were detected in nine patients (44.4%). 28% were grade I–II and 17% were grade III–IV. Disease-free survival at 1 and 3 years was 67 and 44%, respectively. Overall survival at 1 and 3 years was 100 and 88%, respectively. Only cytoreduction was related to worst disease free survival after univariate (p = 0.007) and multivariate (OR 11.639, 95% CI 1.24–109.74, p = 0.03) analyses. Cytoreduction was related to the worst overall survival after univariate analysis (p = 0.046).

Conclusion

Cytoreductive surgery and HIPEC for pseudomyxoma peritonei and appendix tumours in elderly patients it is a procedure with feasible postoperative morbi-mortality and survival outcomes.

Trial registration

researchregistry1587 (retrospectively registered).

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Author information

Authors and Affiliations

  1. Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain

    V. López-López, P. A. Cascales-Campos, E. Gil, A. Gonzalez, J. Gil & P. Parrilla

  2. Radiology Departament, Memorial Sloan Kettering Cancer Center, New York, USA

    J. Arevalo

  3. Hospital Universitario Virgen del Rocio, Sevilla, Andalucia, Spain

    F. C. Muñoz-Casares

  4. Hospital Universitario De Torrecárdenas, Almería, Andalucia, Spain

    J. T. Melero

  5. Hospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain

    P. Barrios & I. Ramos

  6. Hospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain

    R. Morales

  7. Hospital Universitario De Fuenlabrada, Madrid, Spain

    G. Ortega

  8. Hospital General Universitario Valencia, Valencia, Spain

    B. Camps

  9. Hospital General Universitario Gregorio Marañón, Madrid, Spain

    L. González-Bayón

  10. Hospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain

    P. Bretcha-Boix & J. Farré-Alegre

  11. MD Anderson Cancer Center, Madrid, Spain

    S. González-Moreno

Authors
  1. V. López-López
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  2. P. A. Cascales-Campos
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  3. E. Gil
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  4. J. Arevalo
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  5. A. Gonzalez
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  6. J. Gil
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  7. F. C. Muñoz-Casares
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  8. J. T. Melero
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  9. P. Barrios
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  10. R. Morales
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  11. I. Ramos
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  12. G. Ortega
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  13. B. Camps
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  14. L. González-Bayón
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  15. P. Bretcha-Boix
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  16. J. Farré-Alegre
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  17. S. González-Moreno
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  18. P. Parrilla
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Corresponding author

Correspondence to P. A. Cascales-Campos.

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López-López, V., Cascales-Campos, P.A., Gil, E. et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei and appendix tumours in elderly patients: Is it justified?. Clin Transl Oncol 19, 1388–1392 (2017). https://doi.org/10.1007/s12094-017-1728-9

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  • DOI: https://doi.org/10.1007/s12094-017-1728-9

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