Skip to main content

Advertisement

SpringerLink
Log in

The use of radiotherapy for early breast cancer in woman at different ages

  • Educational Series – Red Series
  • New Trends in Clinical Oncology
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Age is an important feature at the time of early breast cancer diagnosis. Radiotherapy is a mandatory component of treatment for breast-conserving strategies in early disease stages. Breast radiotherapy has rapidly evolved in the last 20 years. A tendency to less treatment volume (partial-breast irradiation) and less treatment time (hypofractionation) is consolidated in modern radiation oncology practice. Age and risk for local recurrence guide the decision-making process to electro-optimal treatment. Radiotherapy technological versatility offers multiple options for individualized (risk–age adapted) recommendations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–16.

    Article  Google Scholar 

  2. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–41.

    Article  PubMed  Google Scholar 

  3. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–32.

    Article  PubMed  Google Scholar 

  4. Fisher B, Redmond C, Poisson R, Margolese R, Wolmark N, Wickerham L, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989;320:822–8.

    Article  CAS  PubMed  Google Scholar 

  5. Poortmans PM, Collette L, Bartelink H, Struikmans H, Van den Bogaert WF, Fourquet A, et al. The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 “boost versus no boost” trial. Cancer Radiother. 2008;12:565–70.

    Article  CAS  PubMed  Google Scholar 

  6. Morrow M, White J, Moughan J, Owen J, Pajack T, Sylvester J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol. 2001;19:2254–62.

    CAS  PubMed  Google Scholar 

  7. Hooning MJ, Botma A, Baaijens MH, Baaijens MH, Bartelink H, Klijn JG, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:340–1.

    Article  Google Scholar 

  8. van de Velde CJ, Rea D, Seynaeve C, Putter H, Hasenburg A, Vannetzel JM, et al. Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial. Lancet. 2011;377:321–31.

    Article  PubMed  Google Scholar 

  9. Litière S, Werutsky G, Fentiman IS, Rutgers E, Christiaens MR, Van Limbergen E, et al. Breast conserving therapy versus mastectomy for stage I–II breast cancer: 20 year follow-up of the EORTC 10801 phase 3 randomised trial. Lancet Oncol. 2012;13:412–9.

    Article  PubMed  Google Scholar 

  10. Bartelink H, Horiot JC, Poortmans PM, Struikmans H, Van den Bogaert W, Fourquet A, et al. Impact of a higher radiation dose on local control and survival in breast conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol. 2007;25:3259–65.

    Article  PubMed  Google Scholar 

  11. Antonini N, Jones H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881–10882. Radiother Oncol. 2007;82:265–71.

    Article  PubMed  Google Scholar 

  12. Collette S, Collette L, Budiharto T, Horiot JC, Poortmans PM, Struikmans H, et al. Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: a study based on the EORTC trial 22881–10882 ‘‘boost versus no boost’’. Eur J Cancer. 2008;44:2587–99.

    Article  PubMed  Google Scholar 

  13. Yarnold J, Bentzen SM, Coles C, Haviland J. Hypofractionated whole-breast radiotherapy for women with early breast cancer: myths and realities. Int J Radiat Oncol Biol Phys. 2011;79:1–9.

    Article  PubMed  Google Scholar 

  14. Ash DV, Benson EA, Sainsbury JR, Round C, Head C. Seven-year follow-up on 334 patients treated by breast conserving surgery and short course radical postoperative radiotherapy: a report of the Yorkshire Breast Cancer Group. Clin Oncol. 1995;7:93–6.

    Article  CAS  Google Scholar 

  15. Yarnold J, Ashton A, Bliss J, Homewood J, Harper C, Hanson J, et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol. 2005;75:9–17.

    Article  PubMed  Google Scholar 

  16. Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ, et al. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013;14:1086–94.

    Article  PubMed  Google Scholar 

  17. Whelan T, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 2010;362:513–20.

    Article  CAS  PubMed  Google Scholar 

  18. Tsang Y, Haviland J, Venables K, Yarnold J, FAST Trial Management Group. The impact of dose heterogeneity on late normal tissue complication risk after hypofractionated whole breast radiotherapy. Radiother Oncol. 2012;104:143–7.

    Article  PubMed  Google Scholar 

  19. Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, et al. Accelerated partial breast irradiation consensus statement from the American society for radiation oncology (ASTRO). Int J Radiat Oncol Biol Phys. 2009;74:987–1001.

    Article  PubMed  Google Scholar 

  20. Offersen BV, Overgaard M, Kroman N, Overgaard J. Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review. Radiother Oncol. 2009;90:1–13.

    Article  PubMed  Google Scholar 

  21. Bartelink H, Bourgier C, Elkhuizen P. Has partial breast irradiation by IORT or brachytherapy been prematurely introduced into the clinic? Radiother Oncol. 2012;104:139–42.

    Article  PubMed  Google Scholar 

  22. Polgár C, Fodor J, Major T, Sulyok Z, Kásler M. Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol. 2013;108:197–202.

    Article  PubMed  Google Scholar 

  23. Veronesi U, Orecchia R, Luini A, Galimberti V, Zurrida S, Intra M, et al. Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons. Breast Cancer Res Treat. 2010;124:141–51.

    Article  PubMed  Google Scholar 

  24. Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Dell’Acqua V, et al. Accelerated partial breast irradiation with intraoperative electrons: using GEC-ESTRO recommendations as guidance for patient selection. Radiother Oncol. 2013;106:21–7.

    Article  PubMed  Google Scholar 

  25. Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Rotmensz N, et al. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys. 2012;83:806–13.

    Article  PubMed  Google Scholar 

  26. Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol. 2013;14:1269–77.

    Article  PubMed  Google Scholar 

  27. Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, et al. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT—A randomised trial. Lancet. 2014;383:603–13.

    Article  PubMed  Google Scholar 

  28. Poortmans P. Optimal approach in early breast cancer: radiation therapy. Eur J Cancer Suppl. 2013;11:27–36.

    Article  Google Scholar 

  29. Sole CV, Calvo FA. Integrating accelerated partial breast irradiation into clinical practice. Rev Med Chil. 2012;140:1369–70.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Radiation Oncology Department, Hospital General Universitario, Madrid, Spain

    F. A. Calvo

  2. School of Medicine, Complutense University, Madrid, Spain

    F. A. Calvo

  3. Service of Radiation Oncology, Clinica La Luz, Madrid, Spain

    F. A. Calvo, R. Meiriño & M. A. Infante

  4. Radiation Oncology Department, Institut Gustave Roussy Cancer Campus, 39 rue Camille Desmoulins, 94805, Villejuif, France

    C. V. Sole, S. Rivera, H. Marsiglia & E. Deutsch

  5. Molecular Radiotherapy Laboratory INSERM1030, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France

    S. Rivera & E. Deutsch

  6. School of Medicine, Paris-Sud University, Villejuif, France

    S. Rivera & E. Deutsch

  7. Service of Gynecology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    S. Lizarraga

  8. Service of Radiation Oncology, Instituto Oncológico Hospital Provincial de Castellón, Castellón, Spain

    E. Boldo & C. Ferrer

Authors
  1. F. A. Calvo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. V. Sole
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Rivera
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Meiriño
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Lizarraga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. A. Infante
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Boldo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C. Ferrer
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H. Marsiglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. E. Deutsch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. V. Sole.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Calvo, F.A., Sole, C.V., Rivera, S. et al. The use of radiotherapy for early breast cancer in woman at different ages. Clin Transl Oncol 16, 680–685 (2014). https://doi.org/10.1007/s12094-014-1164-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-014-1164-z

Keywords

Search

Navigation