Purpose.
To evaluate the response of advanced squamous cell head and neck carcinoma to a combination of induction chemotherapy and radiotherapy.
Methods.
We present long-term results of a phase II trial of Induction Chemotherapy with UFT 200 mg/m 2 p.o. days 1 to 21, Vinorelbine 25 mg/m 2 i.v. days 1 and 8 and Cisplatin 100 mg/m 2 i.v. day 1 (UFTVP) each 21 days for 4 courses, followed by Radiotherapy concomitant with UFT 100 mg/m 2 p.o. daily and Carboplatin AUC = 0.5 i.v. weekly (RT/UFTJ) in patients (pts) with Non-Resectable Locally Advanced (Stage IV-B) Squamous Cell Head and Neck Carcinoma (IV-B-SCHNC). Primary endpoint was Complete Response to induction UFTVP and secondary endpoints were Disease Free Status Rate after locoregional treatment and long-term Overall Survival. Between 1994 and 1997, 32 pts were included.
Results.
Complete Response to Induction UFTVP was 59% (95% CI: 48%-70%). Main toxicity of UFTVP was G 3,4 neutropenia (94% of pts; 25% developed febrile neutropenia and 1 of this pts dead). After Induction Chemotherapy with UFTVP, 30 pts received radiotherapy and 25 of them received cocomitant Carboplatin and UFT (RT/UFTJ): main toxicity was mucositis (G3-4: 72%) and one patient died during RT/UFTJ because pneumonia. Twenty-five pts (78%) were alive and disease free at the end of the whole treatment. Actuarial 5 year Overall survival is 32%.
Conclusion.
Although toxicity is important, this approach has interesting activity and deserves further investigation.
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An erratum to this article is available at http://dx.doi.org/10.1007/s12094-007-0038-z.
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Rivera, F., Vega-Villegas, M.E., López-Brea, M.F. et al. Long term results of a phase II trial of Induction Chemotherapy with Uracil-Ftegafur (UFT), Vinorelbine and Cisplatin (UFTVP) followed by Radiotherapy concomitant with UFT and Carboplatin (RT/UFTJ) in Non-Resectable Locally Advanced (Stage IV-B) Squamous Cell Head and Neck Carcinoma and Peripheral Blood Stem Cell Support (PBSCS) with Febrile Neutropenia. Clin Transl Oncol 9, 40–47 (2007). https://doi.org/10.1007/s12094-007-0008-5
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DOI: https://doi.org/10.1007/s12094-007-0008-5