Abstract
A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complet response of MCD published, VIH negative, induced with anti CD20.
Similar content being viewed by others
References
Kikuta H, Itakura O, Taneichi K, Kohno M. Tropism of human herpesvirus 8 for peripheral blood lymphocytes in patients with Castleman’s disease. Br J Haematol. 1997;99(4):790–5.
Marcelin AG, Aaron L, Mateus C, Gyan E, Gorin I, Viard JP, Calvez V, Dupin N. Rituximab therapy for HIV-associated Castleman disease. Blood. 2003;102(8): 2786–8.
Kofteridis DP, Tzagarakis N, Mixaki I, Maganas E, Xilouri E, Stathopoulos EN, Eliopoulos GD, Gikas A. Multicentric Castleman’s disease: prolonged remission with anti CD-20 monoclonal antibody in an HIV-infected patient. AIDS. 2004;18(5):585–6.
Gholam D, Vantelon JM, Al-Jijakli A, Bourhis JH. A case of multicentric Castleman’s disease associated with advanced systemic amyloidosis treated with chemotherapy and anti-CD20 monoclonal antibody. Ann Hematol. 2005;82(12):766–8.
Corbellino M, Bassetti G, Scalamogna C, et al. Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy. Blood. 2001; 12:3473–5.
Seggewiss R, Ho AD, Kraemer A. Remarkable response to rituximab in a patient with atypical CD20(++) mantle cell lymphoma of the bone marrow leading to severe pancytopenia. Ann Hematol. 2004;83 (5):316–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cervera Grau, J.M., Esquerdo, G.G., Ferrándiz, C.L. et al. Complete remission in a pancytopenic HIV negative, HHV-8 positive patient with multicentric Castleman’s disease induced with anti-CD20. Clin Transl Oncol 8, 540–541 (2006). https://doi.org/10.1007/s12094-006-0056-2
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s12094-006-0056-2