Journal of Cell Communication and Signaling

, Volume 13, Issue 1, pp 119–120 | Cite as

Remission of fibrosis: rage to the rescue

  • Matthew Alleyn
  • Mason Breitzig
  • Richard Lockey
  • Narasaiah KolliputiEmail author
Bits and Bytes


Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and permanent decline of lung function that eventually leads to expiry. A study published in 2017 performed by Kumar et al. revealed that the disease may not be as irreversible as was once believed. The research discovered a novel role for the receptor for advanced glycation end-products (RAGE) in which it acts as a master regulator for DNA double-strand break repair. In doing so, Kumar et al. may have made a breakthrough that could redefine the translational approaches of IPF.


RAGE DNA repair Fibrosis Nucleus RAGE knockout 


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Copyright information

© The International CCN Society 2018

Authors and Affiliations

  1. 1.Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of MedicineUniversity of South FloridaTampaUSA

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