Journal of Cell Communication and Signaling

, Volume 12, Issue 1, pp 103–112 | Cite as

Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins

RESEARCH ARTICLE

Abstract

Tumours are complex entities, wherein cancer cells interact with myriad soluble, insoluble and cell associated factors. These microenvironmental mediators regulate tumour growth, progression and metastasis, and are produced by cancer cells and by stromal components such as fibroblast, adipocytes and immune cells. Through their ability to bind to extracellular matrix proteins, cell surface receptors and growth factors, matricellular proteins enable a dynamic reciprocity between cancer cells and their microenvironment. Hence, matricellular proteins play a critical role in tumour progression by regulating where and when cancer cells are exposed to key growth factors and regulatory proteins. Recent studies suggest that, in addition to altering Wingless (Wnt) signalling, certain members of the Secreted Frizzled Related Protein (sFRP) family are matricellular in nature. In this review, we outline the importance of matricellular proteins in cancer, and discuss how sFRPs may function to both inhibit and promote cancer progression in a context-dependent manner. By considering the matricellular functionality of sFRPs, we may better understand their apparently paradoxical roles in cancers.

Keywords

secreted Frizzled-Related Proteins matricellular cancer microenvironment stroma 

Notes

Acknowledgements

This work was supported by an Alberta Innovates Health Solutions Translational Health Chair in cancer and a Canadian Breast Cancer Foundation operating grant awarded to LMP. LMP was the recipient of the Peter-Lougheed Premier New Investigator Award from the Canadian Institutes of Health Research. KMV is a Vanier Scholar.

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Copyright information

© The International CCN Society 2017

Authors and Affiliations

  1. 1.Department of Oncology, Faculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada
  2. 2.Department of Anatomy and Cell Biology, Faculty of Medicine and DentistryUniversity of Western OntarioLondonCanada

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