Pilot Experiment: the Effect of Added Flavorants on the Taste and Pleasantness of Mixtures of Glycerol and Propylene Glycol
The US Food and Drug Administration banned most “sweet” flavorants for use in cigarettes due to the concern that sweet flavors appeal to young, beginning smokers. However, many of the same flavors, including fruity and confection-associated aromas (e.g., vanilla), are still used in e-cigarettes. Sweet flavors may have a number of effects, including enhancement of the taste of other ingredients. The current work focused on the impact of model flavorants on the taste of a mixture of propylene glycol and vegetable glycerine, solvents used in most e-cigarettes and related products.
A device delivered mixtures of propylene glycol and vegetable glycerine into the mouth in parallel with puffs of clean air (control) or odorized air. Aromas included two “fruity” esters (“pineapple” and “banana”), two confection-associated aromas (“vanilla” and “caramel/malty”), menthol (not a “sweet” aroma, but commonly used in e-cigarettes), and a “burnt” aroma not expected to enhance flavor. Twenty young adults, aged 18–25, rated the sweetness, bitterness, and pleasantness of all stimuli (within-subjects design).
Both fruity aromas significantly enhanced sweetness, both confection-associated aromas significantly enhanced pleasantness, and the caramel/malty aroma significantly reduced bitterness. Menthol and the “burnt” aroma had no measurable effects on the taste of solvent mixtures.
Some flavorants modulated the taste of solvents commonly used in e-cigarettes in ways consistent with an enhanced sensory profile.
If similar effects occur in actual products, improved flavor profiles could facilitate continued use, particularly in non-smokers experimenting with e-cigarettes and related products.
KeywordsFlavor E-cigarettes Vaping Abuse potential
This work was funded in part by P50-CA-179546, NIH/NCI/FDA, University of Pennsylvania Tobacco Center of Regulatory Science.
Compliance with Ethical Standards
This work was funded in part by P50-CA-179546, NIH/NCI/FDA, and in part by funds from [the authors’ institutions, not specifically listed to comply with double-blind peer review].
Conflict of Interest
PMW currently receives research funding from major food, beverage, and food ingredients companies. None of these companies provided funding for or were in any way involved in the current research. AAS has active research grants from the US National Institutes of Health (NIH) and US Food and Drug Administration (FDA) and has previously been funded by NIH and FDA, as well as a peer-reviewed GRAND grant sponsored by Pfizer (2008–2011). HN has recently been hired as a full-time employee by Kerry, a flavor and nutrition company. PDR declares that she has no potential conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments. All procedures were approved by an Institutional Review Board (IRB) at the University of [not included here to comply with double-blind peer review].
Written, informed consent was obtained from all individual participants in the study, using IRB approved forms, before any study procedures were performed.
- 111th Congress (2009) Family smoking prevention and tobacco control and federal retirement reform. https://www.gpo.gov/fdsys/pkg/PLAW-111publ31/html/PLAW-111publ31.htm. Accessed 27 July 2017.
- Ambrose BK, Day HR, Rostron B, Conway KP, Borek N, Hyland A, Villanti AC (2015) Flavored tobacco product use among US youth aged 12-17 years, 2013-2014. JAMA 314(17):1871. doi: 10.1001/jama.2015.13802
- Bingham AF, Birch GG, de Graaf C, Behan JM, Perring KD (1990) Sensory studies with sucrose-maltol mixtures. Chem Senses 15(4):447–456. doi: 10.1093/chemse/15.4.447
- Carpenter CM, Wayne GF, Pauly JL, Koh HK, Connolly GN (2005) New cigarette brands with flavors that appeal to youth: tobacco marketing strategies. Health Aff (Project Hope) 24(6):1601–1610. doi: 10.1377/hlthaff.24.6.1601
- FDA, Center for Tobacco Products (2016a) http://www.fda.gov/TobaccoProducts/Labeling/RulesRegulationsGuidance/ucm394909.htm
- FDA, Center for Tobacco Products (2016b) https://www.fda.gov/TobaccoProducts/Labeling/ProductsIngredientsComponents/ucm456610.htm
- Giovenco DP, Hammond D, Corey CG, Ambrose BK, Delnevo CD (2015) E-cigarette market trends in traditional U.S. retail channels, 2012-2013. Nicotine Tob Res 17(10):1279–1283. doi: 10.1093/ntr/ntu282
- Isogai T, Wise PM (2016) The effects of odor quality and temporal asynchrony on modulation of taste intensity by retronasal odor. doi: 10.1093/chemse/bjw059
- Krishnan-Sarin S, Morean ME, Camenga DR (2014) E-cigarette use among high school and middle school adolescents in Connecticut. Nicotine Tob Res:1–9. doi: 10.1093/ntr/ntu243
- Lawless HT, Clark CC (1992) Psychological biases in time intensity scaling. Food Technol 46:81–90Google Scholar
- Mcneill A, Brose LS, Calder R, Hitchman SC (2015) E-cigarettes: an evidence update. A report commissioned by Public Health England. Public Health England: 111. www.gov.uk/government/uploads/system/uploads/attachment_data/file/454516/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England.pdf
- Mermelstein R, Fiore MC, Bernstein SL, Delnevo C, Croyle RT, Emmons KM, Eissenberg TE, Hyland A, Ostroff JS, Prochaska J, Ribisi K, Schnoll RA, Sindelar J, Vidrine JI, Winickoff JP, Web Hooper M (2016) Tobacco control research priorities for the next decade: Working group recommendations for 2016–2025. Report to the NCI Board of Scientific Advisors Web site. http://cancercontrol.cancer.gov/pdf/nci-tobacco-control-research-priorities-rpt-feb-2016.pdf
- Pepper JK, Ribisl KM, Brewer NT (2016). Adolescents’ interest in trying flavoured e-cigarettes. Tobacco Control. Published online first: 15 September 2016. doi: 10.1136/tobaccocontrol-2016-053174
- Rosbrook K, Green BG (2016) Sensory effect of menthol and nicotine in an e-cigarette. Nicotine Tob Res. doi: 10.1093/ntr/ntw019
- Sakai N, Kobayakawa T, Gotow N, Saito S, Imada S (2001) Enhancement of sweetness ratings of aspartame by a vanilla odor presented either by orthonasal or retronasal routes. Percept Mot Skills 92(3 Pt 2):1002–1008. doi: 10.2466/pms.2001.92.3c.1002
- U.S. Department of Health and Human Services (2012) Preventing tobacco use among youth and young adults: a report of the surgeon general. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 3[accessed 2016 Apr 14]Google Scholar
- U.S. Department of Health and Human Services (2014) The health consequences of smoking—50 years of progress: a report of the surgeon general. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 17 [accessed 2016 Apr 14]. aahb.wildapricot.org