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The role of collateral veins detected by endosonography in predicting the recurrence of esophageal varices after endoscopic treatment: a systematic review

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Abstract

Endoscopic therapy is the principal method of treatment for esophageal varices. The recurrence of varices is still common following endoscopic treatment. The aim was to identify predictive factors for variceal recurrence detected by endosonography. We performed a systematic review of studies published prior to June 2013. Studies analyzing gastroesophageal collateral veins as risk factors for variceal recurrence after endoscopic treatment were included. The primary outcome was to identify predictive factors for variceal recurrence investigated by endosonography. After a full-text review, 13 studies were included in our analysis. Analysis of risk factors was not possible for all studies included. Perforating veins and periesophageal collateral veins were related to a higher risk of variceal recurrence (OR = 3.93; 95 % CI 1.06–14.51; I 2 = 96 %; OR = 2.29; 95 % CI 1.58–3.33; I 2 = 55 %). Analysis of cardiac intramural veins and paragastric/cardiac collateral veins showed the same trend, but without reaching statistical significance because of the small group size and wide CI (OR = 3.72; 95 % CI 0.14–101.53; I 2 = 91 %; OR = 1.85; 95 % CI 0.84–4.07; I 2 = 0 %). Analysis of other collateral veins as risk factors for variceal recurrence and analysis of risk factors with regard to the endoscopic treatment method was not possible because of the limited number of cases and different methodologies. A positive association between variceal recurrence and type and grade of collateral veins, investigated by endosonography, was demonstrated. Endosonography is a promising tool for predicting recurrence of esophageal varices following endoscopic treatment. These findings should be interpreted with caution because of the heterogeneity of the studies.

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Acknowledgements

No funding has been received for this work.

Compliance with ethical requirements and Conflict of interest

Laura Masalaite, Jonas Valantinas, Juozas Stanaitis declare that they have no ethical conflicts. Laura Masalaite, Jonas Valantinas, Juozas Stanaitis declare that they havo no conflicts of interest. No funding has been recieved for this work.

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Authors and Affiliations

  1. Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital Santariskiu Clinics, Santariskiu str. 2, 08661, Vilnius, Lithuania

    Laura Masalaite, Jonas Valantinas & Juozas Stanaitis

  2. Clinic of Gastroenterology, Nephrourology and Surgery, Medical Faculty, Vilnius University, Vilnius, Lithuania

    Laura Masalaite & Jonas Valantinas

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  1. Laura Masalaite
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  2. Jonas Valantinas
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Correspondence to Laura Masalaite.

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Masalaite, L., Valantinas, J. & Stanaitis, J. The role of collateral veins detected by endosonography in predicting the recurrence of esophageal varices after endoscopic treatment: a systematic review. Hepatol Int 8, 339–351 (2014). https://doi.org/10.1007/s12072-014-9547-3

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  • DOI: https://doi.org/10.1007/s12072-014-9547-3

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