Bleomycin Sclerotherapy in Lymphangiomas of Head and Neck: Prospective Study of 8 Cases
- 92 Downloads
The aim of this study is to evaluate the role of bleomycin as a primary mode of nonsurgical treatment in lymphangiomas of head and neck and study their complications. This is a prospective study of 8 patients diagnosed with lymphangioma of head and neck presenting to ENT department of Tata main Hospital from December 2014 to January 2017. They were clinically and radiologically evaluated and treated with intralesional injection of bleomycin diluted in normal saline. Complete resolution was seen in 62.5% (5/8) of patients, 25% (2/8) had good response while 12.5% (1/8) had a poor response. No major complications were noted apart from fever and inflammation. Intralesional bleomycin can be used as a primary modality of treatment.
KeywordsBleomycin Sclerotherapy Lymphangioma Surgery
Compliance with Ethical Standards
Conflict of interest
Dr. Prateek Kumar Porwal, Dr. K.P. Dubey, Dr. Amit Morey, Dr. Harshita Singh, Dr. Pooja. S and Dr. Alokendu Bose declare that they have no conflict of interest.
Informed Consent was taken from each of the participants, Additional informed consent was obtained from all individual participants for whom identifying information (pictures) is included in this article.
All procedures performed in studies involving human participants were in accordance with the ethical standards of Tata Main Hospital Ethical committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- 1.Pia F, Aluffi P, Olina M (1999) Cystic lymphangioma in the head and neck region. Acta otorhinolaryngologica Italica: organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 19(2):87–90Google Scholar
- 7.Pires AM, Reinehr C, Boff F, Nazar FL (2015) Intralesional bleomycin sclerotherapy of lymphangioma: partial response to treatment. Dermatol Surg Off Publ Am Soc Dermatol Surg 41(1):175–177Google Scholar
- 10.Zulfiqar MA, Zaleha AM, Zakaria Z, Amin T (1999) The treatment of neck lymphangioma with intralesional injection of bleomycin. Med J Malays 54(4):478–481Google Scholar