Abstract
The aim of this study is to evaluate the role of bleomycin as a primary mode of nonsurgical treatment in lymphangiomas of head and neck and study their complications. This is a prospective study of 8 patients diagnosed with lymphangioma of head and neck presenting to ENT department of Tata main Hospital from December 2014 to January 2017. They were clinically and radiologically evaluated and treated with intralesional injection of bleomycin diluted in normal saline. Complete resolution was seen in 62.5% (5/8) of patients, 25% (2/8) had good response while 12.5% (1/8) had a poor response. No major complications were noted apart from fever and inflammation. Intralesional bleomycin can be used as a primary modality of treatment.
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Pia F, Aluffi P, Olina M (1999) Cystic lymphangioma in the head and neck region. Acta otorhinolaryngologica Italica: organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 19(2):87–90
Molitch HI, Unger EC, Witte CL, vanSonnenberg E (1995) Percutaneous sclerotherapy of lymphangiomas. Radiology 194(2):343–347
Kim KH, Sung MW, Roh JL, Han MH (2004) Sclerotherapy for congenital lesions in the head and neck. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol Head Neck Surg 131(3):307–316
Okada A, Kubota A, Fukuzawa M, Imura K, Kamata S (1992) Injection of bleomycin as a primary therapy of cystic lymphangioma. J Pediatr Surg 27(4):440–443
Ogita S, Tsuto T, Nakamura K, Deguchi E, Iwai N (1994) OK-432 therapy in 64 patients with lymphangioma. J Pediatr Surg 29(6):784–785
Rozman Z, Thambidorai RR, Zaleha AM, Zakaria Z, Zulfiqar MA (2011) Lymphangioma: is intralesional bleomycin sclerotherapy effective? Biomed Imaging Interv J 7(3):e18
Pires AM, Reinehr C, Boff F, Nazar FL (2015) Intralesional bleomycin sclerotherapy of lymphangioma: partial response to treatment. Dermatol Surg Off Publ Am Soc Dermatol Surg 41(1):175–177
Erikci V, Hosgor M, Yildiz M, Ornek Y, Aksoy N, Okur O et al (2013) Intralesional bleomycin sclerotherapy in childhood lymphangioma. Turk J Pediatr 55(4):396–400
Tanigawa N, Shimomatsuya T, Takahashi K, Inomata Y, Tanaka K, Satomura K et al (1987) Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion. Cancer 60(4):741–749
Zulfiqar MA, Zaleha AM, Zakaria Z, Amin T (1999) The treatment of neck lymphangioma with intralesional injection of bleomycin. Med J Malays 54(4):478–481
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Dr. Prateek Kumar Porwal, Dr. K.P. Dubey, Dr. Amit Morey, Dr. Harshita Singh, Dr. Pooja. S and Dr. Alokendu Bose declare that they have no conflict of interest.
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Informed Consent was taken from each of the participants, Additional informed consent was obtained from all individual participants for whom identifying information (pictures) is included in this article.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of Tata Main Hospital Ethical committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Porwal, P.K., Dubey, K.P., Morey, A. et al. Bleomycin Sclerotherapy in Lymphangiomas of Head and Neck: Prospective Study of 8 Cases. Indian J Otolaryngol Head Neck Surg 70, 145–148 (2018). https://doi.org/10.1007/s12070-017-1243-x
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DOI: https://doi.org/10.1007/s12070-017-1243-x