Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implications
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This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren’s syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren’s syndrome in our tertiary care hospital. All patients underwent a puretone audiogram, tympanogram and acoustic reflex testing. The results of the tests were correlated with clinical and immunological findings. The frequency of audiometrically confirmed hearing loss in primary Sjögren’s syndrome was estimated to be 78.38 %, though only 17.24 % complained of hearing loss; minimal to mild sensorineural hearing loss were the most common varieties. The commonest finding on tympanometry was ‘A’ type curve and acoustic reflex was absent in 18.92 % of cases. There was no association between hearing loss and age, sicca symptoms, systemic symptoms or immunological test results in primary Sjögren’s syndrome. There was a high prevalence of hearing loss among patients with primary Sjögren’s syndrome, but most patients were unaware of this. Hearing assessment and regular monitoring of hearing thresholds is advisable for all patients with primary Sjögren’s syndrome.
KeywordsAutoimmune disease Sjögren’s syndrome Hearing loss Autoimmune inner ear disease
The authors wish to thank the institutional review board for its financial support toward this study through the fluid research fund.
Compliance with Ethical Standards
Conflict of interest
C. V. Thanooja, Ann Mary Augustine, Anjali Lepcha, Pulukool Sandhya, Amit Kumar Tyagi, Debashish Danda, Achamma Balraj declare that they have no conflict of interest.
This study was funded by a research grant from the institution.
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional review board and ethics committee and with the 1964 Helsinki declaration and its later amendments.
Informed consent was obtained from all individual participants included in the study.
- 1.Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61(6):554–558CrossRefPubMedPubMedCentralGoogle Scholar
- 2.Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H et al (2012) American College of Rheumatology classification criteria for Sjögren’s syndrome: a data-driven, expert consensus approach in the Sjögren’s international collaborative clinical alliance cohort. Arthritis Care Res 64(4):475–487CrossRefGoogle Scholar
- 11.Rauch SD, Cohen MA, Ruckenstein MJ (2010) Autoimmune inner ear disease. In: Flint PW, Haughey PH, Lund VJ, Niparko JK, Richardson MA, Robbins KY (eds) Cummings otolaryngology head and neck surgery, 5th edn. MOSBY Elsevier, PhiladelphiaGoogle Scholar
- 16.Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A (2002) Hearing loss evaluation of Sjögren’s syndrome using distortion product otoacoustic emissions. ActaOtolaryngol Suppl 548:20–25Google Scholar
- 20.Katz J, Burkard RF (2002) Handbook of clinical audiology, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar