Comparison of the Transient Evoked Otoacoustic Emissions (TEOAEs) and Distortion Products Otoacoustic Emissions (DPOAEs) in Normal Hearing Subjects With and Without Tinnitus

  • Maryam Emadi
  • Mohammad Rezaei
  • Sirvan Najafi
  • Ali Faramarzi
  • Farhad Farahani
Original Article


The aim of this study was to investigate the possible role of cochlear outer hair cell function with TEOAE and DPOAE tests in patients with normal hearing and tinnitus. 25 tinnitus patients with normal hearing sensitivity selected as study group. Control group consist of 50 normal hearing subjects without tinnitus. All subjects had thresholds below 25 dBHL at frequencies 250–8,000 Hz, tympanogram type A and normal acoustic reflex thresholds. TEOAE were recorded with click stimulus at 80 dB SPL at 1,000, 2,000, 3,000 and 4000 Hz. DPOAE were measured at frequencies 1,000–8,000 Hz and intensity of L1 55 dB SPL and L2 65 dB SPL. Amplitude of DPOAE and TEOAE were decreased in all frequencies in study group. There was significant difference regarding prevalence abnormal TEOAE and DPOAE between study group and control group. There was relationship between dysfunction of outer hair cells and tinnitus in subjects with normal hearing.


Tinnitus Otoacoustic emission Outer hair cell 



We are very grateful to the patients and individuals who participated in this study. The research was supported by Hamadan University of Medical Sciences and Health Services.

Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publicatiosn of this article.


  1. 1.
    Heller AJ (2003) Classification and epidemiology of tinnitus. Otolaryngol Clin N Am 36(2):239–248CrossRefGoogle Scholar
  2. 2.
    Andersson G, Eriksson J, Lundh L-G, Lyttkens L (2000) Tinnitus and cognitive interferenceA stroop paradigm study. J Speech Lang Hear Res 43(5):1168–1173CrossRefPubMedGoogle Scholar
  3. 3.
    Mrena R, Savolainen S, Kuokkanen JT, Ylikoski J (2002) Characteristics of tinnitus induced by acute acoustic trauma: a long-term follow-up. Audiol Neurotol 7(2):122–130CrossRefGoogle Scholar
  4. 4.
    Puel J-L, Ruel JEROM, Guitton M, Wang J et al (2002) The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. Audiol Neurotol 7(1):49–54CrossRefGoogle Scholar
  5. 5.
    Fechter LD, Gd C, Rao D (2002) Chemical asphyxiants and noise. Noise Health 4(14):49PubMedGoogle Scholar
  6. 6.
    Shiomi Y, Tsuji J, Naito Y, Fujiki N, Yamamoto N (1997) Characteristics of DPOAE audiogram in tinnitus patients. Hear Res 108(1):83–88CrossRefPubMedGoogle Scholar
  7. 7.
    Kaltenbach JA (2011) Tinnitus: models and mechanisms. Hear Res 276(1):52–60CrossRefPubMedGoogle Scholar
  8. 8.
    Noreña AJ, Farley BJ (2013) Tinnitus-related neural activity: theories of generation, propagation, and centralization. Hear Res 295:161–171CrossRefPubMedGoogle Scholar
  9. 9.
    Assaf S, Jamous NA, Hroot A, Tubishi K, Husban A, Hamasha K et al (2010) Otoacoustic emissions and tinnitus in normal hearing. JRMS 17(2):27–31Google Scholar
  10. 10.
    Kemp DT (2002) Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull 63(1):223–241CrossRefPubMedGoogle Scholar
  11. 11.
    Snow JB (2004) Tinnitus: theory and management. PMPH-USA, SheltonGoogle Scholar
  12. 12.
    Ami M, Abdullah A, Awang MA, Liyab B, Saim L (2008) Relation of distortion product otoacoustic emission with tinnitus. Laryngoscope 118(4):712–717CrossRefPubMedGoogle Scholar
  13. 13.
    Kim JH (2006) Tinnitus in noise-induced hearing loss. Korean J Aerosp Environ Med 16(1):9–14Google Scholar
  14. 14.
    Chéry-Croze S, Moulin A, Collet L, Morgon A (1994) Is the test of medial efferent system function a relevant investigation in tinnitus? Br J Audiol 28(1):13–25CrossRefPubMedGoogle Scholar
  15. 15.
    Gouveris H, Maurer J, Mann W (2005) DPOAE-grams in patients with acute tonal tinnitus. Otolaryngol Head Neck Surg 132(4):550–553CrossRefPubMedGoogle Scholar
  16. 16.
    Janssen T, Boege P, Oestreicher E, Arnold W (2000) Tinnitus and 2f1−f2 distortion product otoacoustic emissions following salicylate overdose. J Acoust Soc Am 107(3):1790–1792CrossRefPubMedGoogle Scholar
  17. 17.
    Norton SJ, Schmidt AR, Stover LJ (1990) Tinnitus and otoacoustic emissions: is there a link? Ear Hear 11(2):159CrossRefPubMedGoogle Scholar
  18. 18.
    Ceranic BJ, Prasher DK, Raglan E, Luxon LM (1998) Tinnitus after head injury: evidence from otoacoustic emissions. J Neurol Neurosurg Psychiatry 65(4):523–529CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Smurzyński J, Hatzopoulos S, Kochanek K, Bartnik G, Raj-Koziak D et al (2012) The relationship between distortion product otoacoustic emissions and extended high-frequency audiometry in tinnitus patients. Part 1: normally hearing patients with unilateral tinnitus. Med Sci Monit 18(12):CR765PubMedPubMedCentralGoogle Scholar
  20. 20.
    Granjeiro RC, Kehrle HM, Bezerra RL, Almeida VF, André LS, Oliveira CA (2008) Transient and distortion product evoked oto-acoustic emissions in normal hearing patients with and without tinnitus. Otolaryngol Head Neck Surg 138(4):502–506CrossRefPubMedGoogle Scholar
  21. 21.
    Thabet EM (2009) Evaluation of tinnitus patients with normal hearing sensitivity using TEOAEs and TEN test. Auris Nasus Larynx 36(6):633–636CrossRefPubMedGoogle Scholar
  22. 22.
    Favero M, Bento RF, Sanchez TG, Nascimento AF (2004) Contralateral suppression of otoacoustic emission in subject with tinnitus. Otolaryngol Head Neck Surg 131(2):P260CrossRefGoogle Scholar
  23. 23.
    Igna CD, Schmidt LP, Smith M, Facchini L, Kang S (2004) Otoacoustic emissions in patients with tinnitus and normal hearing. Otolaryngol Head Neck Surg 131(2):P279CrossRefGoogle Scholar
  24. 24.
    Assaf S, Jamous NA, Hroot A, Tubishi K, Husban A, Hamasha K et al (2010) Otoacoustic emissions and tinnitus in normal hearing. JRMS 17(2):27–31Google Scholar
  25. 25.
    Sztuka A, Pospiech L, Gawron W, Dudek K (2010) DPOAE in estimation of the function of the cochlea in tinnitus patients with normal hearing. Auris Nasus Larynx 37(1):55–60CrossRefPubMedGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2015

Authors and Affiliations

  • Maryam Emadi
    • 1
  • Mohammad Rezaei
    • 1
  • Sirvan Najafi
    • 2
  • Ali Faramarzi
    • 4
  • Farhad Farahani
    • 3
    • 4
  1. 1.School of Rehabilitation SciencesHamadan University of Medical Sciences & Health ServicesHamadanIran
  2. 2.Hamadan University of Medical Sciences & Health ServicesHamadanIran
  3. 3.School of Public HealthHamadan University of Medical Sciences & Health ServicesHamadanIran
  4. 4.Department of Otolaryngology, School of MedicineHamadan University of Medical Sciences & Health ServicesHamadanIran

Personalised recommendations