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Clinical relationships between the rs2212020 and rs189897 polymorphisms of the ITGA9 gene and epithelial ovarian cancer

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Abstract

To better understand the role of integrin subunit alpha 9 (ITGA9) gene polymorphism in epithelial ovarian cancer (EOC), we investigated the distribution of ITGA9 gene polymorphisms (rs2212020 and rs189897) and revealed whether these polymorphisms were associated with a curative effect in EOC. It was found that rs2212020 and rs189897 were correlated significantly with EOC incidence. The frequency of the C allele of rs2212020 was significantly higher in EOC patients than in the control group (\(P=0.009\), \(\upchi ^{2}=6.857\)). The population with the C allele of rs2212020 had a higher EOC risk than the population with the T allele (\(\hbox {hazard ratio}=1.97\), 95.0% \(\hbox {CI} =1.178-3.299\)). Further, our results showed that the CC genotype was a risk factor for EOC. Regarding the association between ITGA9 and the sensitivity to platinum-based chemotherapy in EOC, there were no statistically significant differences in the frequencies of the rs189897 and rs2212020 polymorphisms between the chemosensitive group and the control group. In multivariate analysis, the patients with the TT genotype of rs189897 had longer progression-free survival (PFS) than the patients without this genotype (\(P=0.010\), \(\hbox {OR}=2.491\)). The AT genotype of rs189897 was a risk factor for PFS in EOC. These findings suggested that rs189897 and rs2212020 could play important roles in EOC diagnosis and prognosis.

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Acknowledgements

This work was supported by National Natural Sciences Foundation of China (81672685, 81272975); the Key Planned Science and Technology Project of Hunan Province (2012FJ3084); the Planned Project of Department of Health of Hunan Province (B2011-030, B2012-029); the Natural Science Foundation of Xinjiang Autonomous Region (2017D01C122).

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Authors and Affiliations

  1. Department of Gynecologic Oncology Ward 5, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410006, People’s Republic of China

    Jinyang Liu & Keqiang Zhang

  2. Department of Neurology, Taoyuan People’s Hospital, Changde, Hunan, 415700, People’s Republic of China

    Ting Liu

  3. Key Laboratory of Carcinogenesis of the Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of the Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410078, People’s Republic of China

    Lin Liang, Junyu He, Manying Zhang, Yanshan Ge, Shan Liao & Yanhong Zhou

  4. Cancer Research Institute, Central South University, Changsha, Hunan, 410078, People’s Republic of China

    Lin Liang, Junyu He, Manying Zhang, Yanshan Ge, Shan Liao & Yanhong Zhou

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  1. Jinyang Liu
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  2. Ting Liu
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  3. Lin Liang
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  4. Junyu He
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  6. Yanshan Ge
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  7. Shan Liao
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  8. Yanhong Zhou
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  9. Keqiang Zhang
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Correspondence to Yanhong Zhou or Keqiang Zhang.

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Corresponding editor: H. A. Ranganath

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Liu, J., Liu, T., Liang, L. et al. Clinical relationships between the rs2212020 and rs189897 polymorphisms of the ITGA9 gene and epithelial ovarian cancer. J Genet 98, 28 (2019). https://doi.org/10.1007/s12041-019-1078-1

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  • DOI: https://doi.org/10.1007/s12041-019-1078-1

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