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Lewis acid catalyst system for Diels–Alder reaction

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Abstract

Ca(OTf)2/Bu4NPF6 catalytic system has been illustrated for the synthesis of Diels–Alder adduct for the first time. This procedure tolerates substrate diversity and delivers high yield. Use of environmentally benign catalyst, high yields and substrate diversity are the highlight of the existing method.

Graphic Abstract

Ca(OTf)2, along with n-Bu4NPF6 as the co-catalyst, is shown to be an effective Lewis acidic catalyst system for the Diels–Alder reaction. Apart from being sustainable and efficient, this procedure is robust and products are obtained in near-quantitative yields.

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Acknowledgements

This work is generously supported by the Department of Science and Technology (DST- SERB/ ECR/2015/000363) India to SM.

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Authors and Affiliations

  1. Medicinal Chemistry Laboratory, Department of Physical Sciences, Institute of Advanced Research, Koba Institutional Area, Gandhinagar, Gujarat, 382426, India

    Rishir Kalepu & Satyendra Mishra

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  1. Rishir Kalepu
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  2. Satyendra Mishra
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Contributions

S.M. and R.K. carried out the synthesis, purification, and characterization of the synthesized molecules. S.M. directed the synthetic work and wrote the paper based upon drafts written by R.K.

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Correspondence to Satyendra Mishra.

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Kalepu, R., Mishra, S. Lewis acid catalyst system for Diels–Alder reaction. J Chem Sci 132, 48 (2020). https://doi.org/10.1007/s12039-020-1749-8

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  • DOI: https://doi.org/10.1007/s12039-020-1749-8

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