Niobium pentoxide, a bifunctional solid surface catalyst, has been successfully employed to facilitate the three-component reaction between aldehydes, amines and triethyl phosphite at room temperature under solvent-free conditions to generate α-amino phosphonate in moderate to good yields. The catalyst can be recycled through simple filtration and reused to effect this transformation.
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We thank the SERB, New Delhi for financial (Grant No. CRG/2019/002,960) support. AS acknowledges the UGC for the fellowship. We thank UGC-SAP, Department of Chemistry. We gratefully acknowledge the Department of Chemistry, Pondicherry University for HRMS facility (DST-FIST Sponsored); Central Instrumentation Facility, Pondicherry University for NMR and IR data.
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Sahani, A., Rao, R.S., Vadakkayil, A. et al. Niobium pentoxide, a recyclable heterogeneous solid surface catalyst for the synthesis of α-amino phosphonates. J Chem Sci 133, 4 (2021). https://doi.org/10.1007/s12039-020-01853-7
- α-Amino phosphonates
- Bifunctional catalyst
- Niobium pentoxide
- Kabachnik-fields reaction
- Organophosphorus compounds