Synthesis and characterization of (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol from 2-hydroxy-4,5-dimethylacetophenone

Abstract

This study reports the development of a novel substituted hydrazone prepared from 2-hydroxy-4,5-dimethylacetophenone and hydrazine in alkaline medium at controlled conditions which yields as corresponding hydrazone [(E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol]. The structure of synthesized (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol was elucidated by elemental analysis and spectroscopic techniques like infrared spectroscopy, ultraviolet–visible spectroscopy, high-performance liquid chromatography, proton nuclear magnetic resonance and mass spectrum.

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Acknowledgements

The authors thank Dr. Dilip Thube, PG Department of Chemistry, New Arts, Commerce and Science College Parner, University of Pune; Mr. Sridhar Yerpal, Bhavesh Chemical, Hyderabad; and Mrs. Ashvini Shingade, Mumbai for their valuable guidance and providing necessary facilities.

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Correspondence to Dinkar Gagare.

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Gagare, D., Patil, R., Lokhande, R. et al. Synthesis and characterization of (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol from 2-hydroxy-4,5-dimethylacetophenone. J Chem Sci 132, 88 (2020). https://doi.org/10.1007/s12039-020-01802-4

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Keywords

  • 2-Hydroxy-4,5-dimethylacetophenone
  • hydrazone
  • hydrazine