Journal of Chemical Sciences

, Volume 129, Issue 10, pp 1549–1557 | Cite as

Expeditious synthesis of coumarin-pyridone conjugates molecules and their anti-microbial evaluation

  • Rajni Khajuria
  • Sheena Mahajan
  • Ambica
  • Kamal K Kapoor
Regular Article
  • 126 Downloads

Abstract

An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2o exhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms.

Graphical Abstract

Expedient synthesis of coumarin-pyridone conjugate molecules has been reported via one-pot, three-component reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones, ethyl 2-nitroacetate and ammonium acetate. Anti-microbial activity of these compounds was evaluated and the results indicated that some of the compounds exhibited mild anti-bacterial activity and good inhibitory potential against the tested fungal organisms.

Keywords

(E)-3-(3-arylacryloyl)-2H-chromen-2-ones ethyl 2-nitroacetate 6-(2-oxo-2H-chromen-3-yl)-4-arylpyridin-2(1H)-ones anti-bacterial anti-fungal 

Notes

Acknowledgements

The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities, Department of Science and Technology, GOI, New Delhi for funding (Project No. SR/S1/OC-38/2010) and NMR facility under PURSE.

Supplementary material

12039_2017_1362_MOESM1_ESM.docx (2.5 mb)
Supplementary material 1 (docx 2545 KB)

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Copyright information

© Indian Academy of Sciences 2017

Authors and Affiliations

  • Rajni Khajuria
    • 1
    • 2
  • Sheena Mahajan
    • 1
  • Ambica
    • 3
  • Kamal K Kapoor
    • 1
  1. 1.Department of ChemistryUniversity of JammuJammuIndia
  2. 2.Department of Chemistry and Chemical SciencesCentral University of JammuJammuIndia
  3. 3.Department of ChemistryGovernment Degree CollegeKathuaIndia

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