Expeditious synthesis of coumarin-pyridone conjugates molecules and their anti-microbial evaluation
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An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2o exhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms.
Keywords(E)-3-(3-arylacryloyl)-2H-chromen-2-ones ethyl 2-nitroacetate 6-(2-oxo-2H-chromen-3-yl)-4-arylpyridin-2(1H)-ones anti-bacterial anti-fungal
The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities, Department of Science and Technology, GOI, New Delhi for funding (Project No. SR/S1/OC-38/2010) and NMR facility under PURSE.
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