For mammals to develop properly, master regulatory genes must be repressed appropriately in a heritable manner. This review concerns the Polycomb Repressive Complex 1 (PRC1) family and the relationship between the establishment of repression and memory of the repressed state. The primary focus is on the CBX family of proteins in PRC1 complexes and their role in both chromatin compaction and phase separation. These two activities are linked and might contribute to both repression and memory.
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We thank ES Jaensch, T Oei, and AJ Plys for critical reading of the manuscript. This work was supported by the NIH grant R35GM131743 to REK and the Urology Care Foundation Research Scholar Award Program to JK.
This article is part of the Topical Collection: Chromatin Biology and Epigenetics.
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Kim, J., Kingston, R.E. The CBX family of proteins in transcriptional repression and memory. J Biosci 45, 16 (2020). https://doi.org/10.1007/s12038-019-9972-5
- epigenetic memory
- nucleosome compaction
- phase separation
- Polycomb Repressive Complex