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Interrelation of Ca2+ and PE_PGRS proteins during Mycobacterium tuberculosis pathogenesis

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Abstract

In today’s era tuberculosis is a major threat to human population. The lethality of this disease is caused by very efficiently thrived bacteria Mycobacterium tuberculosis (M. tuberculosis). Ca2+ plays crucial role in maintenance of cellular homeostasis. Bacilli survival in human alveolar macrophages majorly depends on disruption in Ca2+ signaling. Bacilli sustainability in phagosome lies in the interruption of phagolysosomal fusion, which is possible because of low intracellular Ca2+ concentration. Bacilli contain various Ca2+ binding proteins which help in regulation of Ca2+ signaling for its own benefit. For the survival of pathogen, it requires alteration in normal Ca2+ concentration in healthy cell. In this review we aim to find the various Ca2+ binding domains which are present in several Ca2+ binding proteins of M. tuberculosis and variety of roles played by Ca2+ to survive bacilli within host cell. This manuscript emphasizes the Ca2+ binding domains present in PE_PGRS group of gene family and their functionality in M. tuberculosis survival and pathogenesis.

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Abbreviations

Ca2+ :

calcium ions

CAMLP:

calmodulin-like proteins

M. tuberculosis :

Mycobacterium tuberculosis

PE:

Pro-Glu sequence

PE_PGRS:

proline-glutamic polymorphic GC-rich repetitive sequence

TB:

tuberculosis.

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Acknowledgements

The authors acknowledge financial support from GAP0145 of the Department of Science and Technology and the Council of Scientific and Industrial Research, India.

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  1. CSIR–Institute of Genomics and Integrative Biology, Delhi, 110 007, India

    Laxman S Meena

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  1. Laxman S Meena
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Correspondence to Laxman S Meena.

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Communicated by BJ RAO.

Corresponding editor: BJ Rao

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Meena, L.S. Interrelation of Ca2+ and PE_PGRS proteins during Mycobacterium tuberculosis pathogenesis. J Biosci 44, 24 (2019). https://doi.org/10.1007/s12038-018-9828-4

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