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Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world and commonly associated with insulin resistance and hyperlipidemia. Chlorogenic acid (CG) was reported to have insulin-sensitizing activity and exert hypocholesterolemic and hypoglycemic effect. However, the involvement of CG in NAFLD remains far from being addressed. In this study, a high-fat diet-induced NAFLD rat model was used to investigate the biological roles and underlying mechanism of CG in NAFLD. The results showed that high-fat diet-fed rats exhibited an increase in body weight, glucose tolerance, liver injury, insulin resistance, as well as autophagy and C-Jun N-terminal kinase (JNK) pathway. Nevertheless, all these effects were alleviated by CG treatment. Moreover, angiotensin treatment in CG group activated the JNK pathway, and promoted autophagy, insulin resistance, and liver injury. In conclusion, our findings demonstrated that CG ameliorated liver injury and insulin resistance by suppressing autophagy via inactivation of JNK pathway in a rat model of NAFLD. Therefore, CG might be a potential application for the treatment of NAFLD.

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Acknowledgements

This work was supported by Shaanxi Provincial Natural Science Foundation (2016JM8142)

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Authors and Affiliations

  1. Department of Geratology, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710068, China

    Hua Yan & Ying Zhang

  2. Department of Functional Examination, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710068, China

    Yan-Qiong Gao

  3. Department of Ultrasound, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710068, China

    Huan Wang

  4. Department of Gastroenterology, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710068, China

    Gui-Sheng Liu

  5. Department of Pathology, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710068, China

    Jian-Yuan Lei

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  1. Hua Yan
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  2. Yan-Qiong Gao
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  3. Ying Zhang
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  4. Huan Wang
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  6. Jian-Yuan Lei
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Correspondence to Hua Yan.

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Communicated by ULLAS KOLTHUR.

Corresponding editor: Ullas Kolthur

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Yan, H., Gao, YQ., Zhang, Y. et al. Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease. J Biosci 43, 287–294 (2018). https://doi.org/10.1007/s12038-018-9746-5

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  • DOI: https://doi.org/10.1007/s12038-018-9746-5

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