Journal of Molecular Neuroscience

, Volume 61, Issue 3, pp 359–367 | Cite as

Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease

  • Giampiero Palladino
  • Vincenzina Nicolia
  • Gabor G. Kovacs
  • Sonia Canterini
  • Viviana Ciraci
  • Andrea Fuso
  • Franco Mangia
  • Sigfrido Scarpa
  • Maria Teresa Fiorenza


Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.


TgCRND8 Mouse models of AD Sex-influenced gene expression patterns Aβ-plaques 



This study was supported by the EC 7th Framework Program, Grant No. 278486 “Develage” and Ateneo 2014 Sapienza to SS and MTF.

Supplementary material

12031_2016_865_MOESM1_ESM.pdf (4 mb)
Supplementary Table 1 (PDF 4072 kb)
12031_2016_865_MOESM2_ESM.pdf (8.2 mb)
Supplementary Fig. 1 (PDF 8428 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Giampiero Palladino
    • 1
  • Vincenzina Nicolia
    • 2
  • Gabor G. Kovacs
    • 3
  • Sonia Canterini
    • 1
  • Viviana Ciraci
    • 2
  • Andrea Fuso
    • 1
    • 4
  • Franco Mangia
    • 1
  • Sigfrido Scarpa
    • 2
  • Maria Teresa Fiorenza
    • 1
  1. 1.Department of Psychology, Section of Neuroscience and “Daniel Bovet” Neurobiology Research CenterSapienza University of RomeRomeItaly
  2. 2.Department of Surgery “P. Valdoni”Sapienza University of RomeRomeItaly
  3. 3.Institute of Neurology Medical University of ViennaViennaAustria
  4. 4.European Center for Brain Research (CERC)/IRCCS Santa Lucia FoundationRomeItaly

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