Sporadic Multifocal Gastrinoma Mimicking a Duodenal GIST, in a Patient with MEN1 Gene Polymorphism D418D: an Unusual Case Report

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Fig. 1
Fig. 2

Data Availability

Upon request.



Computed tomography


Enterochromaffin-like cells


Grade of histological differentiation




5-Hydroxyindoleacetic acid

H. pylori :

Helicobacter pylori


Multiple Endocrine Neoplasia type 1


Neuroendocrine tumor


Proton-pump inhibitors


Smooth muscle actin


Zollinger–Ellison syndrome


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Genetic determinations were done at Hamamatsu University School of Medicine. The authors thank Ms. Keiko Ishino for genetic determinations.


This study was funded by Romanian National Authority for Scientific Research, CNCS–UEFISCDI, project number 20 PCCF/2018, code: PN-III-P4-ID-PCCF-2016-0006. The necessary materials were provided by the grant.

Author information




SG drafted the paper and contributed to the histopathological diagnosis; IJ contributed to the histopathological diagnosis and interpretation of immunohistochemical data; CB established the clinical diagnosis and performed the surgical intervention; AP contributed to the revision of literature data; HY and HS performed the interpretation of genetic determinations; HS conferred the final approval for publication. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Simona Gurzu.

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Ethical Approval

The approval of Ethical Committee of Clinical County Emergency Hospital of Targu Mures, Romania, was obtained for data collection.

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Signed informed consent for surgical intervention and publication of data was obtained before surgery.

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Gurzu, S., Jung, I., Borz, C. et al. Sporadic Multifocal Gastrinoma Mimicking a Duodenal GIST, in a Patient with MEN1 Gene Polymorphism D418D: an Unusual Case Report. J Gastrointest Canc 52, 351–354 (2021). https://doi.org/10.1007/s12029-020-00461-5

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