Is it Possible to Increase Survival of Patients with Intrahepatic Cholangiocarcinoma? A Case Report

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2


  1. 1.

    Rajkomar K, Koea JB (2017) Intrahepatic cholangiocarcinoma. Blumgart’s surgery of the liver, biliary tract and pancreas, 6th edition, Elsevier, pp 32-59.

  2. 2.

    Metcalfe MS, Bridgewater FH, Mullin EJ, Mullin EJ, Maddern GJ. Useless and dangerous: fine needle aspiration of hepatic colorectal metastases. BMJ. 2004;328:507–8.

    CAS  Article  Google Scholar 

  3. 3.

    De Jong MC, Nathan H, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, et al. Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol. 2011;29:3140–5.

    Article  Google Scholar 

  4. 4.

    Ribero D, Pinna AD, Guglielmi A, Ponti A, Nuzzo G, Giulini SM, et al. Surgical approaches for long term survival of patients with intrahepatic cholangiocarcinoma: a multi-institutional analysis of 434 patients. Arch Surg. 2012;147:1107–13.

    Article  Google Scholar 

  5. 5.

    Endo I, Gonen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, et al. Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg. 2008;248:84–96.

    Article  Google Scholar 

  6. 6.

    Jan YY, Yeh CN, Yeh TS, Hwang TL, Chen MF. Clinicopathological factors predicting long-term overall survival after hepatectomy for peripheral cholangiocarcinoma. World J Surg. 2005;29:894–8.

    Article  Google Scholar 

  7. 7.

    Yoh T, Hatano E, Seo S, Okuda Y, Fuji H, Ikeno Y, et al. Long-term survival of recurrent intrahepatic cholangiocarcinoma: the impact and selection of repeat surgery. World J Surg. 2018;42:1848–56.

    Article  Google Scholar 

  8. 8.

    Zhang SJ, Hu P, Wang N, Shen Q, Sun AX, Kuang M, et al. Thermal ablation versus repeated hepatic resection for recurrent intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2013;20:3596–602.

    Article  Google Scholar 

  9. 9.

    Si A, Li J, Xing X, Lei Z, Xia Y, Yan Z, et al. Effectiveness of repeat hepatic resection for patients with recurrent intrahepatic cholangiocarcinoma: factors associated with long-term outcomes. Surgery. 2017;161:897–908.

    Article  Google Scholar 

  10. 10.

    Ibrahim SM, Mulcahy MF, Lewandowski RJ, Sato KT, Ryu RK, Masterson EJ, et al. Treatment of unresectable cholangiocarcinoma using yttrium-90 microspheres: results from a pilot study. Cancer. 2008;113:2119–28.

    CAS  Article  Google Scholar 

  11. 11.

    Mouli S, Memon K, Baker T, Benson AB 3rd, Mulcahy MF, Gupta R, et al. Yttrium-90 radioembolization for intrahepatic cholangiocarcinoma: safety, response, and survival analysis. J Vasc Interv Radiol. 2013;24:1227–34.

    Article  Google Scholar 

  12. 12.

    Högberg J, Rizell M, Hultborn R, Svensson J, Henrikson O, Mölne J, et al. Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy. EJNMMI Res. 2014;4:48.

    Article  Google Scholar 

  13. 13.

    Högberg J, Rizell M, Hultborn R, Svensson J, Henrikson O, Mölne J, et al. Simulation model of microsphere distribution for selective internal radiation therapy agrees with observations. Int J Radiat Oncol Biol Phys. 2016;96:414–21.

    Article  Google Scholar 

  14. 14.

    Hemmingsson J, Högberg J, Mölne J, Svensson J, Gjertsson P, Rizell M, et al. Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities. Adv Radiat Oncol. 2018;3:439–46.

    Article  Google Scholar 

  15. 15.

    Dhingra S, Schwartz M, Kim E, Leung NW, Chan M, Lin J, et al. Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yittrium 90-impregnated microspheres: report of two cases. Semin Liver Dis. 2014;34:465–8.

    Article  Google Scholar 

  16. 16.

    Kim JH, Yoon HK, Sung KB, Ko GY, Gwon DI, Shin JH, et al. Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes. Cancer. 2008;113:1614–22.

    Article  Google Scholar 

  17. 17.

    Lau WY, Kennedy AS, Kim YH, Lai HK, Lee RC, Leung TW, et al. Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres. Int J Radiat Oncol Biol Phys. 2012;82:401–7.

    Article  Google Scholar 

  18. 18.

    Robles R, Figueras J, Turrion VS, Margarit C, Moya A, Varo E, et al. Spanish experience in liver transplantation for hilar and peripheral cholangiocarcinoma. Ann Surg. 2004;239:265–71.

    Article  Google Scholar 

  19. 19.

    Sapisochin G, Fernandez de Sevilla E, Echeverri J, Charco R. Liver transplantation for cholangiocarcinoma: current status and new insights. World J Hepatol. 2015;7:2396–403.

    Article  Google Scholar 

  20. 20.

    Sapisochin G, Facciuto M, Rubbia-Brandt L, Marti J, Mehta N, Yao FY, et al. For iCCA international consortium. Liver transplantation for “very early” intrahepatic cholangiocarcinoma: international retrospective study supporting a prospective assessment. Hepatology. 2016;64:1178–88.

    CAS  Article  Google Scholar 

Download references


This manuscript was not supported by any funding.

Author information



Corresponding author

Correspondence to Serdar Topaloglu.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

Written informed consent was obtained from the patient’s relatives for publication of this case report and any accompanying images.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Oguz, S., Kucukaslan, H., Topaloglu, S. et al. Is it Possible to Increase Survival of Patients with Intrahepatic Cholangiocarcinoma? A Case Report. J Gastrointest Canc 52, 342–346 (2021).

Download citation